Objective To observe the sedative effect of lidocaine and propofol on bronchoalveolar lavage (BAL)under mechanical ventilation in ICU.Methods Eighty-six cases of patients with BAL were selected in this study.The patients were divided into:propofol control group(n = 43)and lidocaine and propofol observation group (n =43).The BAL perfusion time,BAL lavage volume,propofol dosage,the frequency of cough,body movement,apnea,hypotension,tachycardia of the patients were recorded.Results The BAL perfusion time and lavage volume was (40±6)min and (156±17)mL in control group,which were lower than(52±6)min and (212 ±23)mL in observation group,respectively(P <0.05 and P <0.01).The propofol dosage was (182±26)mg in control group,which was higher than (158±24)mg in observation group(P <0.05).There was no significant difference in cough and tachycardia frequency between control and observation group(P >0.05).The frequency of movement,apnoea and hypotension was significantly higher in control group than that in observation group (P<0.05 and P <0.01).Conclusion Lidocaine and propofol was beneficial to BAL in ICU patients with mechanical ventilation.It reduced the propofol dosage and adverse reactions related to propofol.It had certain value in clinical application.%目的：观察利多卡因联合异丙酚在重症监护室（ICU）机械通气模式下行支气管肺泡灌洗（BAL）的临床镇静效果。方法选择2014年1月至2015年3月我院急诊科机械通气模式下行 BAL 的患者86例，患者按随机数字表法分为异丙酚对照组和利多卡因联合异丙酚观察组，每组43例。患者 BAL 的灌洗时间、灌洗量、丙泊酚用量、呛咳次数、体动次数、呼吸暂停次数，以及低血压、心动过速次数。结果对照组 BAL 灌洗时间和灌洗量分别为（40±6）min 和（156±17）mL，均显著低于观察组的（52±6）min 和（212±23）mL（P ＜0.05和 P＜0.01）。对照组 BAL 时镇静药物丙泊酚用量为（182±26）mg，显著高于观察组的（158±24）mg（P ＜0．05）。呛咳和心动过速次数在对照组和观察组之间差异无统计学意义（P ＞0．05），但体动次数、呼吸暂停和低血压次数对照组均显著高于观察组（P ＜0．05和 P ＜0．01）。结论利多卡因联合异丙酚有利于 ICU 机械通气患者 BAL操作，减少异丙酚用量，减少了异丙酚相关不良反应的发生，具有一定的临床应用价值。
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