Objective To investigate the relationship between gestational diabetes mellitus (GDM ) and sub‐clinical hypothyroidism (PSCH) .Methods Two hundred cases of high‐risk pregnant women with GDM who un‐derwent pregnant examination in our hospital between February 2014 and February 2015 were selected as the study Subjects .All of them underwent oral glucose tolerance test (OGTT) .According to the glucose tolerance test ,the subjects were divided in to the normal glucose tolerance (NGT ) group (152 cases) and the GDM group (48 ca‐ses) .One hundred cases of pregnant women without high risk of GDM ,who underwent pregnant examination in the same period ,were included in the control group .The positivity of thyroid stimulating hormone (TSH) ,triio‐dothyronine (T3 ) ,thyroid hormones (T4 ) ,free triiodothyronine (FT3 ) ,free thyroxine hormones (FT4 ) and thy‐roid autoantibodies and distribution of iodine nutritional status were compared .The incidence of PSCH was recor‐ded.Results FT4 values of NGT group and the control group were higher than that of GDM group and there was significant difference between NGT group and control group [(9 .2 ± 1 .3) vs (12 .2 ± 1 .4) vs (14 .7 ± 1 .9) pmol/L]( P <0.05) .TPOAb values of NGT group and the control group were lower than those of GDM group [(38 ± 6) vs (30 ± 5) vs (22 ± 4)U/mL]( P <0.05) .The positive rates of autoantibodies in NGT group and the control group (6.6% ,1.0% ) were significantly lower than that in GDM group (20.8% ) ( P <0 .05) .There were sig‐nificant differences in the distribution of iodine nutritional status among GDM group and NGT group ,the control group ( P<0.05) .The incidence rates of PSCH in NGT group and the control group (11 .8% ,7 .0% ) were sig‐nificantly lower than that in GDM group (27 .1% ) ( P <0 .05) .Conclusion GDM can damage the thyroid func‐tion and increase the incidence of PSCH .%目的：探讨妊娠期糖尿病（GDM ）与妊娠期亚临床甲状腺功能减退（PSC H ）的相关性。方法纳入2014年2月至2015年2月入我院孕检的GDM 高危风险孕妇200例作为研究对象，均行口服糖耐量实验（OGTT），根据糖耐量检查情况分为正常糖耐量组（NGT）152例和GDM 48例，选取同期孕检且无GDM 高危因素孕妇100名作为对照组，比较促甲状腺激素（TSH）、三碘甲状腺原氨酸（T3）、甲状腺素（T4）、游离三碘甲状腺原氨酸（FT3）、游离甲状腺素（FT4）、甲状腺自身抗体阳性情况及碘营养状态分布，记录PSCH发生率。结果与GDM 组对比，NGT组和对照组的FT4值较高，NGT 组和对照组间差异有统计学意义[（9.2±1.3）与（12.2±1.4）与（14.7±1.9）pmol／L]（均 P ＜0.05）。与GDM 组对比，NGT组、对照组的 TPOAb值较低[（38±6）与（30±5）与（22±4）U／mL]（均 P ＜0.05）。与GDM组的20.83％对比，NGT组、对照组自身免疫抗体阳性率分别为6．6％、2．0％明显减低（ P ＜0.05）。与GDM组对比，NGT组、对照组碘营养分布状态差异有统计学意义（ P ＜0.05）。与GDM组的27.1％比较，NGT组和对照组 PSCH发生率分别为11.8％、7.0％明显减低（ P ＜0.05）。结论 GDM会损害甲状腺功能，增加PSC H发生率。
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