Objective To investigate the diagnostic value of common blood parameters in activity and severi-ty assessment of ulcerative colitis(UC) ,and their correlation .Methods From August 2009 to August 2014 ,108 cases of UC patients and 55 healthy controls were retrospectively analyzed the clinical data ,blood routine test ,liv-er function ,blood coagulation and red blood cell sedimentation rate (ESR) in Shengjing Hospital affiliated to Chi-na Medical University .Results The level of hemoglobin (Hb) ,mean platelet volume (MPV) ,serum albumin (ALB) in active UC patients were significantly lower than those in the control group and the UC patients in remis-sion .The platelet count (PLT) ,red cell distribution width (RDW) ,D-dimer ,fibrinogen (FIB) and the level of ESR were significantly higher than those of the control group and the UC patients in remission (P<0.05);the levels of Hb ,MPV and ALB in severe UC patients were significantly lower than those in moderate and mild group;PLT ,D-dimer ,FIB ,ESR and RDW in severe UC patients were significantly higher than those of mild and moderate active group (P<0 .05) .Each index in patients with UC are not very ideal ,but the ROC of the combi-nation detection of ESR ,RDW and MPV were 0 .891 .Hb ,MPV and ALB were negative correlated with severity of UC patients(P<0 .05) ,PLT ,RDW ,D-dimer ,FIB and ESR were positively correlated with severity of UC pa-tients(P<0 .05) .Conclusion Common blood parameters test is simple and easy ,can be used as a screening in-dex ,can help early detection of patients with UC ,as early as the other related to improve the examination ,as soon as possible to carry out individual treatment .%目的 探讨常见血液检测指标对溃疡性结肠炎(U C )的诊断、疾病严重程度及相关性的价值.方法 回顾性分析2009年8月至2014年8月中国医科大学附属盛京医院消化科收治的108例U C患者及55名健康对照者的临床资料及检测血常规、肝功能、凝血及红细胞沉降率(ESR)的结果.结果 活动期 UC患者的血红蛋白(Hb)、平均血小板体积(MPV)、血清白蛋白(ALB)水平显著低于对照组及缓解期UC患者 ,而血小板计数(PLT)、红细胞分布宽度(RDW)、D-二聚体、纤维蛋白原(FIB)、ESR的水平显著高于对照组及缓解期UC患者(P<0.05);重度活动UC患者的 Hb、MPV、ALB显著低于中度及轻度活动组 ;PLT、D-二聚体、FIB、ESR、RDW显著高于轻度及中度活动组(P<0.05).各指标在UC患者的活动性均不十分理想 ,但ESR、RDW、MPV三者联合检测的受试者工作特征曲线(ROC)曲线下面积为0 .891;Hb、MPV和ALB与 UC患者严重程度呈负相关(P<0.05) ,PLT、RDW、D-二聚体、FIB、ESR与UC患者严重程度呈正相关.结论 常见血液各指标检查简单易行 ,可作为初筛指标 ,可以帮助早发现UC患者、早完善其他相关检查、尽早地开展个体化的治疗.
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