Due to chemical similarity of nano-hydroxyapatite (nano-HAP) to inorganic component of bone matrix,nano-HAP and its composites have attracted particular attention in the field of regenerative medicine.However,our understanding of the effect and mechanism of nano-HAP on bone regeneration is still fragmentary.In addition,very little is known about the interaction of nano-hydroxyapatite with the body with regards to its toxicity.In this article,the application,mechanism and biological safety of nano-HAP in bone repair will be reviewed.%由于与骨基质矿物质成份的相似性,纳米羟基磷灰石(nano-hydroxyapatite,nano-HAP)及其复合物在生物医疗再生领域引起了广泛关注.然而,我们对于nano-HAP在骨再生过程中的作用及机制尚未明确.此外,对于nano-HAP对机体是否有毒性仍有争议.本文就其在骨缺损修复方面的应用,促进骨再生的机制和生物安全性作一综述.
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