Objective To investigate factors that affect the 90 day prognosis of acute stroke patients, and whether serum alkaline phosphatase level in acute stage is an independent risk factor for the prognosis of these patients.Methods 210 patients with acute stroke were enrolled from September,2013 to February, 2014.Collection of clinical data was needed and meanwhile carried on the marks of NIHSS.The outcomes were followed up at the end of 90 day,simultaneously carried on the marks of mRS,which defined the score >2 as the poor prognosis group,≤2 as the good one.Results In enrollde 199 patients (ratio of losing was 5. 24%),47(23.62%)had a poor functional outcome.NIHSS score at admission (P =0.001),atrial fibrillation (P =0.003),alkaline phosphatase (P =0.001),uric acid (P =0.027)and high sensitivity C reactive protein (P =0.001)are factors that affect the 90 day prognosis of acute stroke patients.NIHSS score at admission(P=0.001 ,OR=1 .46,95%CI =1 .24-1 .71)and alkaline phosphatase(P =0.001 ,OR = 1 .13,95%CI = 1 .09 -1 .1 8)are independent risk factors for the prognosis of acute stroke patients.Conclusions NIHSS score at ad-mission,atrial fibrillation,alkaline phosphatase,uric acidand high sensitivity C reactive protein are factors that affect the 90 day prognosis in acute stroke patients.Serum alkaline phosphatase level in acute stage? is? an in-dependent risk factor for? the prognosis of acute stroke patients.%目的：探讨急性脑梗死90 d 预后相关的影响因素及急性期碱性磷酸酶(ALP)水平是否为急性脑梗死预后的独立危险因子。方法收集2013年9月~2014年2月于中国医科大学附属盛京医院神经内科住院治疗的急性脑梗死患者210例,全面收集与预后有关的临床资料并进行 NIHSS 量表评分,并于90 d后行短期预后随访,进行 mRS 量表评分；将 mRS 评分>2分定义为预后不良组,≤2分定义为预后良好组,对2组所收集资料进行统计分析。结果210例患者进入研究队列,90 d 后失访11例,失访率为5.24%,最终进入研究队列的患者为199例,其中47例(23.62%)发生预后不良事件。入院时 NIHSS 评分(P =0.001)、心房颤动病史(P =0.003)、碱性磷酸酶(P =0.001)、尿酸(P =0.027)以及超敏 C 反应蛋白(P =0.001)为急性脑梗塞90 d 预后的影响因素。入院时 NIHSS 评分(P =0.001,OR=1.46,95%CI =1.24~1.71)、碱性磷酸酶(P =0.001,OR=1.13,95%CI =1.09~ 1.18)为脑梗死预后的独立危险因子。结论入院时 NIHSS 评分、心房颤动病史、碱性磷酸酶、尿酸以及超敏 C 反应蛋白为急性脑梗塞90天预后的影响因素；NIHSS 评分和急性期碱性磷酸酶水平为脑梗死患者90 d 预后的独立危险因子。
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