Objective To compare the clinical effects and safety of different endoscopic biliary stent in the treatment of malignant obstruction. Methods A total of 90 malignant obstruction patients with endoscopic stent implantation from July 2011 to May 2018 were selected, and divided into group A and group B by using random number table, with 45 cases in each group. Patients in group A were given biliary plastic stent implantation, while patients in group B were given biliary metallic stent implantation. The success rate of stent implantation, indices of liver function and complications were compared between the two groups. Results There was no statistical difference in the success rate of stent implantation between the two groups ( P＞ 0. 05). After 3 days of surgery, the levels of glutaminyl transferase ( GGT), alkaline phosphatase ( ALP), direct bilirubin ( DBIL), total bilirubin ( TBIL) in group B were lower than those in group A ( P ＜ 0. 05). The incidence rate of postoperative complications in group B was lower than that in group A ( P ＜ 0. 05). Conclusion Endoscopic metallic biliary stent implantation in the treatment of malignant obstruction can effectively improve patients' liver function and decrease the incidence of complications, which is of safety.%目的 比较恶性胆道梗阻患者经内镜下不同胆道支架治疗的临床效果及其安全性.方法 选取2011年7月—2018年5月择期行内镜下支架置入术的恶性胆道梗阻患者90例,根据随机数表法分为A组和B组,每组45例.A组置入胆道单塑料支架,B组置入胆道金属支架,对比两组支架置入成功、肝功能指标及并发症情况.结果 两组支架置入成功率对比,差异无统计学意义(P＞ 0.05); B组术后3 d时谷氨酰转移酶(glutaminyl transferase,GGT)、碱性磷酸酶(alkaline phosphatase,ALP)、直接胆红素(direct bilirubin,DBIL)及总胆红素(total bilirubin,TBIL)水平均低于A组,差异有统计学意义(P ＜0.05); B组术后并发症发生率低于A组,差异有统计学意义(P ＜0.05).结论 内镜下置入金属胆道金属支架可有效改善患者肝功能,降低并发症发生率,安全性高.
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