Background:Clinical and histopathological differential diagnosis is usually impossible in drug-induced lichen planus(LP)and idiopathic LP.Naproxen is a nonsteroidal anti-inflammatory drug,which is widely used for its analgesic,antipyretic and anti-inflammatory effects.To the best of our knowledge,two case reports on naproxen-induced LP have been reported.Methods:Fifty-five patients with LP,and a history of naproxen intake before their eruption,were investigated.Results:Twenty-five patients(45.5%)had a history of naproxen intake prior to their eruption without any other medication.Twelv1e patients(21.8%)had a history of simultaneous use of naproxen with other drugs that were reported as inducers of LP.Eighteen patients(32.7%)had given a history of using naproxen together with drugs that had not been previously reported as inducers of LP.Moreover,in 42 patients,eruptive-type LP development after naproxen intake,is an interesting observation.New lesions were not observed after the cessation of naproxen intake in any of the patients.Conclusion:Naproxen might be accepted as an important inducer for LP,especially for the eruptive form.
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