目的：探讨脂蛋白相关磷脂酶A2（Lp-PLA2）预测冠状动脉介入术后再狭窄的价值。方法冠状动脉介入治疗的患者200例，术前检测Lp-PLA2水平，根据结果将患者分为观察组119例（Lp-PLA2≥200ng/ml）和对照组81例（Lp-PLA2<200ng/ml）。两组患者均给予冠心病Ⅱ级预防治疗，术后对患者进行1年随访，比较两组患者再狭窄和主要心脑血管事件的发生率。结果观察组Lp-PLA2水平显著高于对照组[（278.6±68.3）vs（178.2±36.8）ng/ml]，差异有统计学意义（P<0.05）。通过1年随访，与对照组比较，观察组的再狭窄、死亡、非致死心肌梗死、非致死脑卒中比例明显升高[（9.24%vs6.17%），（5.88%vs3.70%），（4.20%vs2.47%），（5.04%vs3.70%）]，差异均有统计学意义（P<0.05）。结论 Lp-PLA2升高提示再狭窄和主要心脑血管事件增加，术前检测Lp-PLA2有预测价值。%Objective To explore the value of lipoprotein associated phospholipase A2(Lp-PLA2)to predict restenosis after percutaneous coronary intervention(PCI). Methods 200 PCI patients were enrolled in this study,and divided into observation group(n=119,Lp-PLA2≥200ng/mL) and control group(n=81,Lp-PLA2<200ng/mL) according to the Lp-PLA2 level before operation.All patients were given medicines based on secondary prevention of coronary artery disease and follow-up regularly,observe restenosis cases and major cardiovascular events between two groups.Results The Lp-PLA2 level of the observation group was significantly higher(278.6±68.3 vs 178.2±36.8)ng/mL,with a significant difference(P<0.05).After one year follow-up,compared with the control group,the total restenosis,death,nonfatal myocardial infarction and nonfatal stroke were higher[(9.24%vs6.17%),(5.88%vs3.70%),(4.20%vs2.47%),(5.04%vs3.70%)],there were significant differences(P<0.05). Conclusion The increase of Lp-PLA2 indicates the increased risk of restenosis and major cardiovascular events, preoperative testing Lp-PLA2 have predictive value.
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