Objective To investigate the risk factors on depression after migraine. Methods Clinical data of 594 patients were analyzed retrospectively. Migraine. Some factors maybe influencing depression after migraine were statistically analyzed by univariate and multivariate binary logistic regression analysis. Factors were evaluated by ROC curve. Results 104 patients suffered from depression after migraine in 594 patients with migraine.4 factors had statistics differences(P<0.05)by univariate analysis. Time of disease(OR: 1.053,P=0.001),genetic background (OR: 4.332,P=4.332),dizziness (OR: 3.890,P=3.890),chronic migraine (OR: 27.282,P=27.282) were the independent risk factors on depression after migraine proved by multivariate analysis. The area under ROC curve for chronic migraine is 0.8059.Conclusion History time,genetic background,dizziness,chronic migraine were valuable factors for predicting depression after migraine.%目的：探讨偏头痛合并出现抑郁症的危险因素。方法回顾性分析594例偏头痛患者临床资料，对可能影响偏头痛合并出现抑郁症的若干指标进行单因素、多因素logistic回归分析，通过ROC曲线评价各指标的预测价值。结果594例偏头痛患者，合并出现抑郁症104例，单因素分析患病时间等4个因素差异有统计学意义（P<0.05），多因素分析患病时间（OR：1.053，P=0.001）、遗传背景（OR：4.332， P=0.000）、头晕（OR：3.890，P=0.000）、慢性偏头痛（OR：27.282，P=0.000）为偏头痛合并出现抑郁症的独立危险因素。其中慢性偏头痛ROC曲线下面积达0.8059。结论患病时间、遗传背景、头晕症状、慢性偏头痛对偏头痛合并出现抑郁症具有预测价值。
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