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首页> 中文期刊> 《浙江临床医学》 >不同剂量特拉唑嗪治疗输尿管支架管相关症状的疗效评价

不同剂量特拉唑嗪治疗输尿管支架管相关症状的疗效评价

         
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目的 探讨不同剂量的特拉唑嗪治疗输尿管碎石术后患者输尿管支架管相关症状的疗效.方法 选取输尿管碎石术后留置输尿管D-J管的患者100例,随机分成4组,各25例.对照组未予特殊干预,A组给予特拉唑嗪1mg,1次/d;B组给予特拉唑嗪2mg,1次/d;C组给予特拉唑嗪5mg,1次/d,疗程为术后4周.所有患者均在输尿管碎石术后第1周及第4周完成输尿管支架管症状调查表(USSQ).结果 与对照组比较,所有药物治疗组患者排尿症状、躯体疼痛症状、身体一般状况、工作能力情况、性生活情况平均评分均下降.与A组比较,B组、C组患者排尿症状、躯体疼痛症状、身体一般状况、工作能力情况、性生活情况评分均有明显改善,组间差异有统计学意义(P0.05).结论 特拉唑嗪能够明显改善输尿管支架管相关症状,且2mg治疗效果最佳,明显提高患者的生活质量.随着剂量的增大,其临床疗效强度无明显差异.%Objective To?investigate?the?effect?of?different?doses?of?terazosin?on?stent-related?symptoms?in?patients?after?ureteral?lithotripsy.?Methods? 100?cases?after?ureterolotripsy?were?randomly?divided?into?4?groups,the?control?group(n=25)was?not?given?special?intervention,group?A(n=25)was?given?trazosin?1mg,1?times?/d,B?group(n=25)?was?given?trazosin?2mg,1/d,C?group(n=25)was?given?trazosin,1?times, 4?weeks?after?the?operation.?All?patients?completed?the?Ureteral?Stent?Symptom?Questionnaire(USSQ)at?week?1?and?week?4?after?ureteral?lithotripsy.?Results? 1.Compared?with?the?control?group,the?average?scores?of?urination?symptoms,somatic?pain,general?physical?condition,working?ability?and?sexual?life?were?decreased?in?all?the?treatment?groups.?2.?Compared?with?group?A,group?B?was?significantly?improved?by?trazosin?2mg?and?C?group?treated?with?trazosin?5mg?for?urination,body?pain,body?general,work?ability?and?sex?life.?The?difference?between?groups?was?statistically?significant (P0.05).?Conclusion? Terazosin?can?significantly?improve?the?symptoms?of?ureteral?stent?related?symptoms?and?the?quality?of?life?of?patients,2?mg?treatment?is?the?best.?There?is?no?significant?difference?in?clinical?efficacy?with?the?increase?of?dose.

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