Objective To discuss the technique,therapeutic effect and complications of CT-guided Interstitial implantation of IodIne-125 seeds for the treatment of malignant solid tumor. Methods 31 cases of cancer patients were selected from August 2010 to May 2017,Iodine 125 was implanted in the tumor lesion by CT-guided treatment planning system(TPS).After treatment,CT was regularly reviewed to evaluate the treatment effect and adverse reactions. Results 31 cases of tumor patients were followed up to 12 months after operation,9 cases of CR,17 cases of PR,4 cases of NC,and 1 case of PD. 1,3,6 and 12 months follow-up,the total effective rates(CR+PR)were 87.1,80.6,80.6 and 83.9 respectively. 24 cases of lung cancer,5 cases of CR and 16 cases of PR,the total effective rate was 87.5%. Complication Included pneumothorax 6 and hemoptysis 4.No serious complications or treatment-related radiation injuries occurred. Conclusion CT-guided implantation of iodine-125 seeds is safe and effective in the treatment of malignant solid tumors,and has a high local control rate.%目的 探讨CT导向下经皮穿刺植入125I粒子治疗恶性实体肿瘤的方法、疗效及并发症.方法 选取2010年8月至2017年5月间31例恶性实体肿瘤患者,根据CT图像及TPS治疗计划系统计算靶病灶植入粒子数量;CT引导下经皮穿刺分次植入125I粒子.治疗后定期复查CT,评价治疗效果及不良反应.结果 31例恶性实体肿瘤患者术后随访12个月,肿瘤完全缓解(CR)9例,部分缓解(PR)17例,无变化(NC)4例,进展(PD)1例,1、3、6、12个月随访,总有效率(CR+PR)分别为87.1%、80.6%、80.6%、83.9%.其中的24例肺癌患者, CR 5例,PR 16例,总有效率87.5%.31例患者中,并发症主要包括术中气胸6例、咳血4例.少量胸腔积液3例,未见严重并发症.结论 CT导向下125I放射性粒子植入治疗恶性实体肿瘤安全,具有肯定的近期疗效及较高的肿瘤局部控制率.
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