A monoclinic crystal form of casein kinase 1 δ

机译：酪蛋白激酶1δ的单斜晶型

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摘要

Casein kinase 1 δ (CK1δ) is a regulatory enzyme in the mammalian circadian oscillator and represents a potential pharmacological target for modulating circadian rhythms. Crystal structures of four different polymorphs of CK1δ have previously been determined and this article reports the crystallization and structure determination of a new crystal form belonging to space group P21. Comparison of CK1δ crystal structures reveals few conformational differences within the C-terminal lobe, but more significant movements of the β-sheet region of the N-terminal lobe were observed.

机译：酪蛋白激酶1δ（CK1δ）是哺乳动物昼夜节律振荡器中的一种调节酶，代表了调节昼夜节律的潜在药理学靶标。先前已经确定了CK1δ的四种不同多晶型物的晶体结构，本文报道了属于空间群P21的一种新晶型的结晶和结构确定。 CK1δ晶体结构的比较显示C端叶内几乎没有构象差异，但观察到N端叶的β折叠区域的运动更为明显。

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期刊名称 Acta Crystallographica Section F: Structural Biology and Crystallization Communications
作者
Nicholas A. Zeringo; Lea Murphy; Eric A. McCloskey; Loren Rohal; John J. Bellizzi III;
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作者单位

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年(卷),期 2013(69),Pt 10
年度 2013
页码 1077–1083
总页数 7
原文格式 PDF
正文语种
中图分类分子生物学;生化遗传学;生化药理学;生物物理学;
关键词
casein kinase 1 δ polymorphism;

机译：酪蛋白激酶1δ;多态性;

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专利

1. A monoclinic crystal form of casein kinase 1 delta [J] . Zeringo Nicholas A., Murphy Lea, McCloskey Eric A., Acta crystallographica, Section F. Structural biology and crystallization communications . 2013,第10期

机译：酪蛋白激酶1δ的单斜晶型
2. The Ste locus, a component of the parasitic cry-Ste system of Drosophila melanogaster, encodes a protein that forms crystals in primary spermatocytes and mimics properties of the beta subunit of casein kinase 2. [J] . Bozzetti MP, Massari S, Finelli P, Proceedings of the National Academy of Sciences of the United States of America . 1995,第13期

机译：Ste位点是果蝇果蝇寄生Cry-Ste系统的组成部分，它编码一种蛋白质，该蛋白质在原代精母细胞中形成晶体，并模仿酪蛋白激酶2的β亚基的性质。
3. Casein kinase II is required for proper cell division and acts as a negative regulator of centrosome duplication in Caenorhabditis elegans embryos Casein kinase II is required for proper cell division and acts as a negative regulator of centrosome duplication in Caenorhabditis elegans embryos Casein kinase II is required for proper cell division and acts as a negative regulator of centrosome duplication in Caenorhabditis elegans embryos [J] . Michael D. Stubenvoll, Lauren E. DeMeyer, Megan M. Kabara, Biology Open . 2017,第1期

机译：酪蛋白激酶II是适当的细胞分裂所必需的，并且在秀丽隐杆线虫胚胎中充当着中心体复制的负调节剂适当的细胞分裂，并在秀丽隐杆线虫胚胎中充当着中心体复制的负调节剂
4. TRANSGENIC EXPRESSION OF YEAST CASEIN KINASE 1 ISOFORM YCK2AS A MEANS OF CONFERRING SALT TOLERANCE TO COTTON [C] . Michael J. Wheeler, Dalton R. Gossett, Lucy C. Robinson, Beltwide Cotton Conference . 2004

机译：酵母酪蛋白激酶1同种型Yck2as的转基因表达是赋予棉花耐盐性的方法
5. Crystal structure of mammalian casein kinase I exhibits basis for phosphate recognition by a protein kinase family. [D] . Longenecker, Kenton Lamar. 1997

机译：哺乳动物酪蛋白激酶I的晶体结构显示了蛋白激酶家族识别磷酸盐的基础。
6. The Ste locus a component of the parasitic cry-Ste system of Drosophila melanogaster encodes a protein that forms crystals in primary spermatocytes and mimics properties of the beta subunit of casein kinase 2. [O] . M P Bozzetti, S Massari, P Finelli, 1995

机译：Ste位点是果蝇果蝇寄生Cry-Ste系统的组成部分它编码一种蛋白质该蛋白质在原代精母细胞中形成晶体并模仿酪蛋白激酶2的β亚基的性质。
7. The Ste locus, a component of the parasitic cry-Ste system of Drosophila melanogaster, encodes a protein that forms crystals in primary spermatocytes and mimics properties of the β subunit of casein kinase 2. [O] . BOZZETTI M. P, MASSARI S, FINELLI P, 1995

机译：Ste位点是果蝇果蝇寄生Cry-Ste系统的组成部分，它编码一种蛋白质，该蛋白质在原代精母细胞中形成晶体并模仿酪蛋白激酶2的β亚基的性质。
8. Functional Role of the Casein Kinase I (CKI) Family in the Transforming Growth Factor-Beta (TGF-Beta) Signaling Pathway [R] . Waddell, D. , Liberati, N. T. , Wang, X. 2003

机译：酪蛋白激酶I（CKI）家族在转化生长因子-β（TGF-β）信号通路中的功能作用

A monoclinic crystal form of casein kinase 1 δ

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