A monoclinic crystal form of casein kinase 1 delta

Zeringo Nicholas A.; Murphy Lea; McCloskey Eric A.; Rohal Loren; Bellizzi John J. III

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A monoclinic crystal form of casein kinase 1 delta

机译：酪蛋白激酶1δ的单斜晶型

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Casein kinase 1 delta (CK1 delta) is a regulatory enzyme in the mammalian circadian oscillator and represents a potential pharmacological target for modulating circadian rhythms. Crystal structures of four different polymorphs of CK1 delta have previously been determined and this article reports the crystallization and structure determination of a new crystal form belonging to space group P2(1). Comparison of CK1 delta crystal structures reveals few conformational differences within the C-terminal lobe, but more significant movements of the beta-sheet region of the N-terminal lobe were observed.

机译：酪蛋白激酶1δ（CK1δ）是哺乳动物昼夜节律振荡器中的调节酶，并且代表用于调节昼夜节律的潜在药理学靶标。先前已经确定了CK1δ的四个不同多晶型物的晶体结构，本文报道了属于空间群P2（1）的新晶型的结晶和结构确定。 CK1δ晶体结构的比较表明，C末端叶内几乎没有构象差异，但观察到N末端叶的β-折叠区域的运动更为明显。

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《Acta crystallographica, Section F. Structural biology and crystallization communications》 |2013年第10期|共7页
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Zeringo Nicholas A.; Murphy Lea; McCloskey Eric A.; Rohal Loren; Bellizzi John J. III;
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1. A monoclinic crystal form of casein kinase 1 delta [J] . Zeringo Nicholas A., Murphy Lea, McCloskey Eric A., Acta crystallographica, Section F. Structural biology and crystallization communications . 2013,第10期

机译：酪蛋白激酶1δ的单斜晶型
2. The Ste locus, a component of the parasitic cry-Ste system of Drosophila melanogaster, encodes a protein that forms crystals in primary spermatocytes and mimics properties of the beta subunit of casein kinase 2. [J] . Bozzetti MP, Massari S, Finelli P, Proceedings of the National Academy of Sciences of the United States of America . 1995,第13期

机译：Ste位点是果蝇果蝇寄生Cry-Ste系统的组成部分，它编码一种蛋白质，该蛋白质在原代精母细胞中形成晶体，并模仿酪蛋白激酶2的β亚基的性质。
3. Inhibition of casein kinase I delta alters mitotic spindle formation and induces apoptosis in trophoblast cells [J] . Martin St?ter, Ana-Maria Bamberger, Bilnaz Aslan, Oncogene . 2005,第54期

机译：抑制酪蛋白激酶I Delta改变有丝分裂主轴形成并诱导滋养细胞细胞凋亡
4. TRANSGENIC EXPRESSION OF YEAST CASEIN KINASE 1 ISOFORM YCK2AS A MEANS OF CONFERRING SALT TOLERANCE TO COTTON [C] . Michael J. Wheeler, Dalton R. Gossett, Lucy C. Robinson, Beltwide Cotton Conference . 2004

机译：酵母酪蛋白激酶1同种型Yck2as的转基因表达是赋予棉花耐盐性的方法
5. Crystal structure of mammalian casein kinase I exhibits basis for phosphate recognition by a protein kinase family. [D] . Longenecker, Kenton Lamar. 1997

机译：哺乳动物酪蛋白激酶I的晶体结构显示了蛋白激酶家族识别磷酸盐的基础。
6. A monoclinic crystal form of casein kinase 1 δ [O] . Nicholas A. Zeringo, Lea Murphy, Eric A. McCloskey, 2013

机译：酪蛋白激酶1δ的单斜晶型
7. p53 is phosphorylated in vitro and in vivo by the delta and epsilon isoforms of casein kinase 1 and enhances the level of casein kinase 1 delta in response to topoisomerase-directed drugs [O] . U Knippschild, D M Milne, L E Campbell, 1997

机译：P53通过酪蛋白激酶1的δ和ε异构体体外和体内磷酸化，并增强酪蛋白激酶1δ的水平，响应于拓扑酶活化药物
8. Functional Role of the Casein Kinase I (CKI) Family in the Transforming Growth Factor-Beta (TGF-Beta) Signaling Pathway [R] . Waddell, D. , Liberati, N. T. , Wang, X. 2003

机译：酪蛋白激酶I（CKI）家族在转化生长因子-β（TGF-β）信号通路中的功能作用

A monoclinic crystal form of casein kinase 1 delta

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