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首页> 美国卫生研究院文献>British Journal of Industrial Medicine >Respiratory cancer in chrysotile textile and mining industries: exposure inferences from lung analysis.
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Respiratory cancer in chrysotile textile and mining industries: exposure inferences from lung analysis.

机译：温石棉纺织和采矿业中的呼吸道癌症：肺部分析的暴露推断。

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In an attempt to explain the much greater risk of respiratory cancer at the same cumulative exposure in asbestos textile workers in Charleston, South Carolina, than in Quebec miners and millers, both exposed to chrysotile from the same source, 161 lung tissue samples taken at necropsy from dead cohort members were analysed by transmission electron microscopy. Altogether 1828 chrysotile and 3270 tremolite fibres were identified; in both cohorts tremolite predominated and fibre dimensions were closely similar. Lung fibre concentrations were analysed statistically (a) in 32 paired subjects matched for duration of employment and time from last employment to death and (b) in 136 subjects stratified by the same time variables. Both analyses indicated that the Quebec/Charleston ratios for chrysotile fibre concentration in lung tissue were even higher than the corresponding ratios of estimated exposure intensity (mpcf). After allowance for the fact that regression analyses suggested that the proportion of tremolite in dust was probably 2.5 times higher in Thetford Mines, Quebec, than in Charleston, the results from both matched pair and stratification analyses of tremolite fibre concentrations in lung were almost the same as for chrysotile. It is concluded that neither fibre dimensional differences nor errors in estimation of exposure can explain the higher risks of lung cancer observed in asbestos textile workers. The possible co-carcinogenic role of mineral oil used in the past in asbestos textile plants to control dust provides an alternative hypothesis deserving consideration.
机译：为了解释在南卡罗来纳州查尔斯顿的石棉纺织工人在相同的累积暴露下，罹患呼吸道癌的风险要比魁北克的矿工和磨坊工高得多，魁北克的矿工和磨坊工都暴露于相同的温石棉，尸检时采集了161个肺组织通过透射电子显微镜分析死去的队列成员的细胞。共鉴定出1828个温石棉和3270个透闪石纤维；在这两个人群中，透闪石占主导，纤维尺寸非常相似。对（a）匹配就业时间和从上次就业到死亡的时间匹配的32位配对受试者中的肺纤维浓度进行统计分析，（b）136份由相同时间变量分层的受试者。两项分析均表明，肺组织中温石棉纤维浓度的魁北克/查尔斯顿比率甚至高于估计的暴露强度（mpcf）的相应比率。考虑到回归分析表明，魁北克塞特福德矿山中透闪石的含量可能比查尔斯顿高出2.5倍，配对和成对分析结果均与肺中透闪石纤维浓度的结果几乎相同至于温石棉结论是，纤维的尺寸差异或暴露估算的误差均不能解释石棉纺织工人中患肺癌的较高风险。过去在石棉纺织厂中使用矿物油来控制粉尘的可能的致癌作用提供了另一种假设，值得考虑。

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