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首页> 美国卫生研究院文献>British Journal of Pharmacology and Chemotherapy >Effects of repeated infusions of substance P and vasoactive intestinal peptide on the weights of salivary glands subjected to atrophying influences in rats.
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Effects of repeated infusions of substance P and vasoactive intestinal peptide on the weights of salivary glands subjected to atrophying influences in rats.

机译：反复输注P物质和血管活性肠肽对受到萎缩影响的唾液腺重量的影响。

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1. The long-term influence of substance P (SP) and vasoactive intestinal peptide (VIP) on rat salivary gland weight was investigated after parasympathetic denervation or on feeding soft food. 2. The parotid gland lost about one-third of its weight within 4-5 days following parasympathetic post-ganglionic denervation or change in dietary regimen, from pellets to liquid diet, thought to reduce nerve reflex activity. 3. Daily i.v. infusions with SP or VIP diminished or largely prevented the fall in parotid gland weight, whereas infusions with pentagastrin, bethanechol and saline had no effect. The infusions were preceded by administration of alpha- and beta-adrenoceptor antagonists; these antagonists were also given to the control animals. 4. The effect of SP and VIP on the parotid gland weight appeared to be related to cell size rather than to cell number, as judged by measurements of RNA and DNA. 5. Observations on the two other major salivary glands underlined the fact that different gland types in the same animal behave differently. Parasympathetic preganglionic denervation (decentralization) lowered the weights of the sublingual and submandibular glands, whereas liquid diet only reduced the weight of the sublingual gland. SP and VIP did not affect the weights of the submandibular glands, but VIP prevented the slight fall in sublingual gland weight induced by liquid diet. 6. The present results suggest a trophic role in rats for SP and VIP on parotid glands and for VIP on sublingual glands. Such an influence may be exerted naturally as a result of their release from nerves containing these peptides around acini.
机译：1.研究了副交感神经支配后或饲喂软性食物对P物质（SP）和血管活性肠肽（VIP）对大鼠唾液腺重量的长期影响。 2.副交感神经节后神经支配失调或饮食方案（从小球状改为流质饮食）改变后，腮腺在4-5天内失去了约三分之一的体重，这被认为会降低神经反射活动。 3.每日i.v. SP或VIP输注减少或很大程度上防止了腮腺重量的下降，而五肽胃泌素，苯乙二酚和生理盐水输注则无效果。在输注之前先使用α-和β-肾上腺素受体拮抗剂。这些拮抗剂也被给予对照动物。 4.根据RNA和DNA的测定，SP和VIP对腮腺重量的影响似乎与细胞大小有关，而不与细胞数量有关。 5.对另外两个主要唾液腺的观察结果表明，同一只动物的不同腺体表现不同。副交感神经节前去神经（去中心化）降低了舌下和颌下腺的重量，而流质饮食仅减轻了舌下腺的重量。 SP和VIP不会影响下颌下腺的重量，但是VIP可以防止流食引起的舌下腺轻度下降。 6.目前的结果表明，大鼠的腮腺SP和VIP和舌下腺VIP的营养作用。这种影响可能是由于它们从腺泡周围含有这些肽的神经中释放出来而自然产生的。

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