Objective To study the changes of plasma gastrin (Gas), substance P (SP) and vascoactive intestinal peptide (VIP) among children with recurrent abdominal pain and their family members,and to explore if there is the rule of the changes.Methods The fasting plasma Gas, SP and VIP were determined by radioimmunoassay method among 30 children with recurrent abdominal pain, and 45 family members including first-degree relatives and second-degree relatives as well as 35 normal healthy children and 20 normal healthy adults. Individuals were divided into five groups:children with recurrent abdominal pain (study group 1), family members with recurrent abdominal pain (study group 2), normal healthy children (control group1), family adults without recurrent abdominal pain (control group2) and normal healthy adults (control group3) . The whole family members of 7 children with recurrent abdominal pain were focused on and analysed.Results 55 of 130 volunteers were with recurrent abdominal pain including 30 children and 25 adults. There were 22 adults with and 20 adults without recurrent abdominal pain in the whole family members of 7 children with recurrent abdominal pain. The fasting plasma Gas content had no difference between study group 1 and control group1 ( <0.05), but the levels of fasting plasma SP and VIP were both in decrease and had difference between study group 1 and control group1 (<0.05) .The fasting plasma Gas,SP and VIP had no difference between study group 2 and control group 2 ( >0.05) .The levels of fasting plasma Gas content had no difference between study group 2 and control group 3 (>0.05),but the levels of fasting plasma SP and VIP were both in increase and had difference between study group 2 and control group3. The fasting plasma Gas content had no difference between country group 1 and control group3 ( <0.05),but the levels of fasting plasma SP and VIP had difference between country group 1 and control group3 ( <0.01) .The levels of fasting plasma SP and VIP had no difference between study group 1 and study group 2 ( <0.05) .The levels of fasting plasma Gas, SP and VIP content had no difference among the whole family members of 7 children with recurrent abdominal pain including 22 adult members with and 20 adult members without recurrent abdominal pain (>0.05) .Conclusions There are the same plasma Gas contents in normal children and adults.However, the plasma SP and VIP contents are higher in normal children than ones in normal adults. The plasma SP and VIP contents are lower in children with recurrent abdominal pain than ones in normal children. The plasma SP and VIP contents are higher in adults with recurrent abdominal pain than ones in normal adults. These suggested that the increases of plasma SP and VIP may have a close relationship with the pathogenesis of children and adults with recurrent abdominal pain. The contents of plasma Gas, SP and VIP were consistent in the whole family members of 7 children with recurrent abdominal pain. It suggested that the secretion of gastrointestinal hormone is disorder in the families with recurrent abdominal pain.%目的：研究反复腹痛患儿空腹血浆中胃泌素（Gas）、P物质（SP）及血管活性肠肽（VIP）水平的变化与反复腹痛的关系．探讨反复腹痛患儿及其家庭成员血浆中Gas、SP及VIP的变化规律．方法采用放射免疫检测技术对30例反复腹痛患儿、反复腹痛患儿家庭的45名一级亲属及二级亲属、35例正常健康儿童和20例正常成人的空腹血浆中Gas、SP、VIP进行测定．根据有无反复腹痛分为5组：反复腹痛患儿组（研究组1）、家庭反复腹痛成人组（研究组2）、正常儿童组（对照组1）、家庭无腹痛成人组（对照组2）和健康成人组（对照组3）．并对7个完整的反复腹痛患儿家庭成员血浆中Gas、SP、VIP进行测定和分析．结果所有受检者共有130人，反复腹痛患者共有55人，其中反复腹痛患儿30人，反复腹痛成人25人；7个反复腹痛患儿家庭中，反复腹痛成人22人，无腹痛成人20人．研究组1血浆Gas含量与对照组1比较差异无统计学意义（＞0.05），但研究组1血浆SP、VIP含量与对照组1比较均明显下降，其差异有统计学意义（＜0.05）．研究组2血浆Gas、SP和VIP含量与对照组2比较差异无统计学意义（＞0.05），研究组2血浆Gas含量与对照组3比较差异无统计学意义（＞0.05），但研究组2血浆SP、VIP含量与对照组3比较均升高，差异有统计学意义（＜0.05）；对照组1与对照组3血浆Gas含量比较差异无统计学意义（＞0.05），而对照组1与对照组3血浆SP和VIP含量比较差异均有统计学意义（＜0.01）．研究组1与研究组2的血浆SP和VIP含量比较差异无统计学意义（＞0.05）．7个反复腹痛家庭中反复腹痛患儿组、反复腹痛成人组和无反复腹痛成人组空腹血浆中的Gas、SP、VIP含量比较差异无统计学意义（＞0.05）．结论正常儿童和正常成人血浆Gas的含量为相同水平，而正常儿童血浆SP和VIP的含量高于正常成人．反复腹痛患儿血浆SP和VIP水平低于正常儿童，反复腹痛成人血浆SP和VIP水平高于正常成人，提示反复腹痛患儿和成人的发病可能与SP和VIP分泌紊乱也有关．7个反复腹痛患儿及其家庭成员中血浆Gas、SP、VIP的含量为相同水平，提示其家庭的胃肠激素分泌紊乱在同一水平．
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