• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>British Journal of Pharmacology and Chemotherapy >Effect of alpha 2-adrenoceptor agonists on gastric pepsin and acid secretion in the rat.
【2h】

Effect of alpha 2-adrenoceptor agonists on gastric pepsin and acid secretion in the rat.

机译：α2肾上腺素受体激动剂对大鼠胃蛋白酶和胃酸分泌的影响。

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

1. The purpose of the present study was to analyze the effects of the alpha 2-adrenoceptor agonists clonidine, guanabenz, detomidine and medetomidine on pepsin secretion in conscious rats provided with gastric chronic fistula and to compare this with acid secretion. 2. Basal interdigestive gastric secretion, which is mainly neurally driven in the rat, and the secretion directly stimulated by the two main stimulants of chief cells, cholecystokinin octapeptide (CCK8) and methacholine, were studied. 3. Basal secretion of pepsin and acid was inhibited by all four drugs with comparable EC50S. 4. CCK-stimulated pepsin and acid secretion was less sensitive than basal pepsin and acid secretion to alpha 2-adrenoceptor inhibition. 5. Methacholine-stimulated pepsin and acid secretion was not changed by clonidine and guanabenz; methacholine-stimulated acid was even marginally increased by clonidine. 6. These results do not favour the presence of alpha 2-receptors on chief cells in the rat stomach. They rather suggest that pepsin inhibition by alpha 2-adrenoceptor agonists is indirect and due to central or peripheral inhibition of the discharge of nerve fibres activating pepsin secretion.
机译：1.本研究的目的是分析α2-肾上腺素受体激动剂可乐定，瓜纳本斯，地托米定和美托咪定对患有胃慢性瘘的清醒大鼠胃蛋白酶分泌的影响，并将其与酸分泌进行比较。 2.研究了大鼠消化道胃底分泌物，其主要是神经驱动的，并研究了主要细胞的两种主要刺激物胆囊收缩素八肽（CCK8）和乙酰甲胆碱直接刺激的分泌。 3.所有四种具有相似EC50S的药物均抑制了胃蛋白酶和胃酸的基础分泌。 4. CCK刺激的胃蛋白酶和胃酸分泌对α2-肾上腺素受体的抑制作用不如基础胃蛋白酶和胃酸分泌。 5.可乐定和瓜纳贝斯不改变甲胆碱刺激的胃蛋白酶和酸的分泌。可乐定甚至会稍微增加乙酰甲胆碱刺激的酸。 6.这些结果不利于大鼠胃中主要细胞上存在α2受体。他们宁愿暗示α2肾上腺素受体激动剂对胃蛋白酶的抑制作用是间接的，并且是由于中枢或外周抑制了激活胃蛋白酶分泌的神经纤维的释放。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号