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首页> 美国卫生研究院文献>The British Journal of Venereal Diseases >Sensitivity requirements for the point of care diagnosis of Chlamydia trachomatis and Neisseria gonorrhoeae in women
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Sensitivity requirements for the point of care diagnosis of Chlamydia trachomatis and Neisseria gonorrhoeae in women

机译：女性沙眼衣原体和淋病奈瑟菌的护理点诊断的敏感性要求

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>Background/objectives: Most current tests for Neisseria gonorrhoeae and Chlmydia trachomatis require the support of a laboratory, and results are not usually available before the patient has left the clinic. This delay can lead to patients not returning for treatment and may allow further STI transmission to occur. Current rapid point of care (POC) STI tests and the syndromic approach are less sensitive than gold standard tests, but allow treatment at the initial visit. This study estimates the required sensitivity of POC tests that ensures as many STIs are averted as with current gold standard tests. >Methods: A mathematical model is developed to compare the STIs averted using different STI diagnostic methods. Data from Benin, South Africa, Tanzania, and England are used to explore how the required sensitivity differs between settings. >Results: The required sensitivity of a POC test is low if there is significant STI transmission during the delay in treatment for the gold standard test and/or few women return for treatment. For example, the required sensitivity of a POC test for C trachomatis is 50% (gold standard test sensitivity is 90%) if either 55% return for treatment and there is no STI transmission, or 80% return for treatment and 50% of infected women infect their partner during the delay in treatment. Furthermore, in these settings a POC test of moderate sensitivity can lead to significantly more STI averted than the gold standard test. >Conclusions: These results support the use of moderate sensitivity POC tests in scenarios where many women will not return for treatment, and in populations where the delay in treatment would result in significant STI transmission.
机译：>背景/目标：当前对淋病奈瑟菌和沙眼衣原体的大多数检测都需要实验室的支持，而且通常在患者离开诊所之前无法获得结果。这种延迟可能导致患者无法返回治疗，并可能导致进一步的STI传播。当前的快速护理点（POC）STI测试和综合症方法不如金标准测试敏感，但可以在初次就诊时进行治疗。这项研究估计了POC测试所需的敏感性，以确保避免与当前的金标准测试一样多的STI。 >方法：建立了数学模型，以比较使用不同STI诊断方法避免的STI。来自贝宁，南非，坦桑尼亚和英国的数据用于探索所需灵敏度在不同设置之间的差异。 >结果：如果在金标准测试延误治疗期间有明显的STI传播和/或很少女性返回治疗，则POC测试所需的敏感性较低。例如，如果55％的治疗回报且没有STI传播，或者80％的治疗回报和50％的感染者，POC检测对沙眼衣原体的敏感性要求为50％（金标准检测灵敏度为90％）妇女在延误治疗期间感染伴侣。此外，在这些设置中，中等灵敏度的POC测试可能会比金标准测试导致更多的STI避免。 >结论：这些结果支持在许多妇女无法返回治疗的情况下以及治疗延迟会导致严重的性传播疾病的人群中使用中度敏感性POC测试。

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