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首页> 美国卫生研究院文献>British Medical Journal >Benzodiazepine use in pregnancy and major malformations or oral cleft: meta-analysis of cohort and case-control studies
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Benzodiazepine use in pregnancy and major malformations or oral cleft: meta-analysis of cohort and case-control studies

机译：苯二氮卓类药物在妊娠和严重畸形或口腔裂隙中的使用：队列和病例对照研究的荟萃分析

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>Objective: To determine if exposure to benzodiazepines during the first trimester of pregnancy increases risk of major malformations or cleft lip or palate. >Design: Meta-analysis. >Setting: Studies from 1966 to present. >Subjects: Studies were located with Medline, Embase, Reprotox, and from references of textbooks, reviews, and included articles. Included studies were original, concurrently controlled studies in any language. >Interventions: Data extraction and quality assessment were done independently and in duplicate. >Main outcome measures: Maternal exposure to benzodiazepines in at least the first trimester; incidence of major malformations or oral cleft alone, measured as odds ratios and 95% confidence intervals with a random effects model. >Results: Of over 1400 studies reviewed, 74 were retrieved and 23 included. In the analysis of cohort studies fetal exposure to benzodiazepine was not associated with major malformations (odds ratio 0.90; 95% confidence interval 0.61 to 1.35) or oral cleft (1.19; 0.34 to 4.15). Analysis of case-control studies showed an association between exposure to benzodiazepines and development of major malformations (3.01; 1.32 to 6.84) or oral cleft alone (1.79; 1.13 to 2.82). >Conclusions: Pooled data from cohort studies showed no association between fetal exposure to benzodiazepines and the risk of major malformations or oral cleft. On the basis of pooled data from case-control studies, however, there was a significant increased risk for major malformations or oral cleft alone. Until more research is reported, level 2 ultrasonography should be used to rule out visible forms of cleft lip. Key messages class="unordered" style="list-style-type:disc">Pooled data from cohort studies showed no apparent association between fetal exposure to benzodiazepines and the risk for major malformations or oral cleft Data from case-control studies showed that risk for major malformations or oral cleft alone was increased Until more studies are done, it is prudent to perform level 2 ultrasonography to rule out visible forms of cleft lip
机译：>目的：确定在怀孕的前三个月接触苯二氮卓类是否会增加出现严重畸形或唇裂或or裂的风险。 >设计：荟萃分析。 >设置：研究范围为1966年至今。 >主题：研究通过Medline，Embase，Reprotox进行，并来自教科书，评论和参考文章。纳入的研究是任何语言的原始同时对照研究。 >干预措施：数据提取和质量评估是独立进行的，一式两份。 >主要结局指标：至少在孕早期，孕妇应接触苯二氮卓类药物；严重畸形或仅口腔裂的发生率，使用随机效应模型以比值比和95％置信区间衡量。 >结果：在所审查的1400多项研究中，检索了74项研究，其中包括23项。在队列研究的分析中，胎儿暴露于苯并二氮杂与主要畸形（奇数比为0.90； 95％置信区间0.61至1.35）或口腔裂口（1.19； 0.34至4.15）无关。病例对照研究的分析表明，接触苯二氮卓类药物与严重畸形（3.01； 1.32至6.84）或仅口腔裂（1.79； 1.13至2.82）的发展之间存在关联。 >结论：队列研究的汇总数据显示，胎儿暴露于苯二氮卓类药物与重大畸形或口腔c裂的风险之间没有关联。然而，基于病例对照研究的汇总数据，重大畸形或仅口腔裂的风险显着增加。在没有更多研究报道之前，应使用2级超声检查排除可见形式的唇裂。关键消息 class =“ unordered” style =“ list-style-type：disc”> <！-list-behavior = unordered prefix-word = mark-type = disc max-label-size = 0-> < li>队列研究的汇总数据表明，胎儿暴露于苯二氮卓类药物与严重畸形或口腔c裂的风险之间没有明显的关联性 病例对照研究的数据表明，仅严重畸形或口腔c裂的风险增加了 在进行更多研究之前，谨慎进行2级超声检查以排除可见的唇裂形式

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