Multimodal treatment of perianal fistulas in Crohn’s disease: seton versus anti-TNF versus advancement plasty (PISA): study protocol for a randomized controlled trial

机译：克罗恩病肛周瘘管的多模式治疗：seton对比抗TNF对比进步成形术（PISA）：一项随机对照试验的研究方案

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BackgroundCurrently there is no guideline for the treatment of patients with Crohn’s disease and high perianal fistulas. Most patients receive anti-TNF medication, but no long-term results of this expensive medication have been described, nor has its efficiency been compared to surgical strategies. With this study, we hope to provide treatment consensus for daily clinical practice with reduction in costs.

机译：背景技术目前尚无治疗克罗恩氏病和肛周瘘管高的患者的指南。大多数患者接受抗TNF药物治疗，但尚未描述这种昂贵药物的长期效果，也未将其疗效与手术策略进行比较。通过这项研究，我们希望为日常临床实践提供治疗共识，并降低成本。

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期刊名称 Current Controlled Trials in Cardiovascular Medicine
作者
E. Joline de Groof; Christianne J. Buskens; Cyriel Y. Ponsioen; Marcel G. W. Dijkgraaf; Geert R. A. M. D’Haens; Nidhi Srivastava; Gijs J. D. van Acker; Jeroen M. Jansen; Michael F. Gerhards; Gerard Dijkstra; Johan F. M. Lange; Ben J. M. Witteman; Philip M. Kruyt; Apollo Pronk; Sebastiaan A. C. van Tuyl; Alexander Bodelier; Rogier M. P. H. Crolla; Rachel L. West; Wietske W. Vrijland; Esther C. J. Consten; Menno A. Brink; Jurriaan B. Tuynman; Nanne K. H. de Boer; Stephanie O. Breukink; Marieke J. Pierik; Bas Oldenburg; Andrea E. van der Meulen; Bert A. Bonsing; Antonino Spinelli; Silvio Danese; Matteo Sacchi; Janindra Warusavitarne; Ailsa Hart; Nuha A. Yassin; Rory P. Kennelly; Garret J. Cullen; Desmond C. Winter; A. Barney Hawthorne; Jared Torkington; Willem A. Bemelman;
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年(卷),期 2015(16),-1
年度 2015
页码 366
总页数 8
原文格式 PDF
正文语种
中图分类心血管疾病;
关键词
Crohn’s disease Perianal fistula Seton Anti-TNF Advancement plasty Quality of life Cost-effectiveness;

机译：克罗恩病;肛周瘘;塞顿;抗TNF;整形;生活质量;成本效益;

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1. Multimodal treatment of perianal fistulas in Crohn’s disease: seton versus anti-TNF versus advancement plasty (PISA): study protocol for a randomized controlled trial [J] . E. J de Groof, Christianne J Buskens, Cyriel Y Ponsioen, Trials . 2015,第1期

机译：克罗恩病肛周瘘管的多模式治疗：seton对比抗TNF对比先进成形术（PISA）：一项随机对照试验的研究方案
2. A multicentre, randomised controlled trial to compare the clinical and cost-effectiveness of Lee Silverman Voice Treatment versus standard NHS Speech and Language Therapy versus control in Parkinson’s disease: a study protocol for a randomised controlled trial [J] . C. M. Sackley, C. Rick, P. Au, Trials . 2020,第1期

机译：多中心，随机对照试验，用于比较Lee Silverman语音治疗的临床和成本效益与标准NHS语言治疗与帕金森病的语言治疗：随机对照试验的研究方案
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4. Curosurf versus survanta in the treatment of neonatal respiratory distress syndrome in preterm infants: results from a randomized, multicenter masked comparison trial. [C] . Acta pharmacologica sinica . 2002

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5. Indirect pulp treatment versus formocresol pulpotomy in human primary molars: A randomized controlled trial. [D] . Roberts, John David. 2009

机译：在人原发性磨牙中间接牙髓治疗与甲酚甲切开术：一项随机对照试验。
6. Treatment of Perianal Fistulas in Crohn’s Disease Seton Versus Anti-TNF Versus Surgical Closure Following Anti-TNF PISA: A Randomised Controlled Trial [O] . Karin A Wasmann, E Joline de Groof, Merel E Stellingwerf, -1

机译：抗TNF PISA塞塞氏病治疗亚洲病塞塞与抗TNF与手术闭合随机对照试验
7. Multimodal treatment of perianal fistulas in Crohn’s disease: seton versus anti-TNF versus advancement plasty (PISA): study protocol for a randomized controlled trial [O] . E. Joline de Groof, Christianne J. Buskens, Cyriel Y. Ponsioen, 2015

机译：克罗恩病肛周瘘管的多模式治疗：seton对比抗TNF对比进步成形术（PISA）：一项随机对照试验的研究方案

Multimodal treatment of perianal fistulas in Crohn’s disease: seton versus anti-TNF versus advancement plasty (PISA): study protocol for a randomized controlled trial

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