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首页> 美国卫生研究院文献>International Journal of Environmental Research and Public Health >Are Office-Based Workplace Interventions Designed to Reduce Sitting Time Cost-Effective Primary Prevention Measures for Cardiovascular Disease? A Systematic Review and Modelled Economic Evaluation
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Are Office-Based Workplace Interventions Designed to Reduce Sitting Time Cost-Effective Primary Prevention Measures for Cardiovascular Disease? A Systematic Review and Modelled Economic Evaluation

机译：以办公室为基础的工作场所干预是否旨在减少就诊时间的具有成本效益的心血管疾病一级预防措施？系统评价和建模经济评估

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Objectives: To assess the cost-effectiveness of workplace-delivered interventions designed to reduce sitting time as primary prevention measures for cardiovascular disease (CVD) in Australia. Methods: A Markov model was developed to simulate the lifetime cost-effectiveness of a workplace intervention for the primary prevention of CVD amongst office-based workers. An updated systematic review and a meta-analysis of workplace interventions that aim to reduce sitting time was conducted to inform the intervention effect. The primary outcome was workplace standing time. An incremental cost-effectiveness ratio (ICER) was calculated for this intervention measured against current practice. Costs (in Australia dollars) and benefits were discounted at 3% annually. Both deterministic (DSA) and probabilistic (PSA) sensitivity analyses were performed. Results: The updated systematic review identified only one new study. Only the multicomponent intervention that included a sit-and-stand workstation showed statistically significant changes in the standing time compared to the control. The intervention was associated with both higher costs ($6820 versus $6524) and benefits (23.28 versus 23.27, quality-adjusted life year, QALYs), generating an ICER of $43,825/QALY. The DSA showed that target age group for the intervention, relative risk of CVD relative to the control and intervention cost were the key determinants of the ICER. The base case results were within the range of the 95% confidence interval and the intervention had a 85.2% probability of being cost-effective. Conclusions: A workplace-delivered intervention in the office-based setting including a sit-and-stand desk component is a cost-effective strategy for the primary prevention of CVD. It offers a new option and location when considering interventions to target the growing CVD burden.
机译：目标：评估工作场所提供的旨在减少就座时间的干预措施的成本效益，以此作为澳大利亚预防心血管疾病（CVD）的主要措施。方法：建立了马尔可夫模型，以模拟工作场所干预措施的终生成本效益，以初步预防上班族发生CVD。进行了旨在减少就座时间的工作场所干预措施的最新系统回顾和荟萃分析，以告知干预效果。主要结果是工作时间。根据当前实践，针对该干预措施计算了增量成本效益比（ICER）。成本（以澳元计）和收益每年折让3％。进行了确定性（DSA）和概率（PSA）敏感性分析。结果：更新的系统评价仅发现一项新研究。与对照组相比，仅包括坐立式工作站的多组分干预措施在站立时间上有统计上的显着变化。该干预措施既带来了较高的成本（6820美元对6524美元），也带来了收益（23.28对23.27，质量调整生命年，QALYs），产生了ICER 43825美元/ QALY。 DSA表明，干预的目标年龄组，相对于对照的CVD相对风险和干预成本是ICER的关键决定因素。基本案例的结果在95％置信区间内，干预措施具有成本效益的可能性为85.2％。结论：在办公室环境中，由工作场所提供的干预措施，包括坐立两用的办公桌组件，是预防CVD的一种经济有效的策略。在考虑针对不断增长的CVD负担的干预措施时，它提供了新的选择和位置。

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