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首页> 美国卫生研究院文献>Infection and Immunity >Note: Adherence of Isogenic Flagellum-Negative Mutants of Helicobacter pylori and Helicobacter mustelae to Human and Ferret Gastric Epithelial Cells
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Note: Adherence of Isogenic Flagellum-Negative Mutants of Helicobacter pylori and Helicobacter mustelae to Human and Ferret Gastric Epithelial Cells

机译：注意：幽门螺杆菌和幽门螺杆菌的同基因鞭毛阴性突变体对人和雪貂胃上皮细胞的粘附

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摘要

Isogenic flagellum-negative mutants of Helicobacter pylori and Helicobacter mustelae were screened for their ability to adhere to primary human and ferret gastric epithelial cells, respectively. We also evaluated the adherence of an H. pylori strain with a mutation in the flbA gene, a homologue of the flbF/lcrD family of genes known to be involved in the regulation of H. pylori flagellar biosynthesis. H. pylori and H. mustelae mutants deficient in production of FlaA or FlaB and mutants deficient in the production of both FlaA and FlaB showed no reduction in adherence to primary human or ferret gastric epithelial cells compared with the wild-type parental strains. However, adherence of the H. pylori flbA mutant to human gastric cells was significantly reduced compared to the adherence of the wild-type strain. These results show that flagella do not play a direct role in promoting adherence of H. pylori or H. mustelae to gastric epithelial cells. However, genes involved in the regulation of H. pylori flagellar biosynthesis may also regulate the production of an adhesin.
机译：筛选幽门螺杆菌和幽门螺杆菌的同基因鞭毛阴性突变体分别粘附至原代人和雪貂胃上皮细胞的能力。我们还评估了幽门螺杆菌菌株与flbA基因突变的粘附性，flbA基因是flbF / lcrD家族已知与幽门螺杆菌鞭毛生物合成调控有关的基因的同源物。与野生型亲本菌株相比，缺乏FlaA或FlaB产生的幽门螺杆菌和H. Mustelae突变体以及缺乏FlaA和FlaB产生的突变体对原代人或雪貂胃上皮细胞的粘附性均未降低。然而，与野生型菌株的粘附相比，幽门螺杆菌flbA突变体对人胃细胞的粘附显着降低。这些结果表明，鞭毛在促进幽门螺杆菌或芥菜对胃上皮细胞的粘附中没有直接作用。但是，参与幽门螺杆菌鞭毛生物合成调控的基因也可能调控粘附素的产生。

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