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首页> 美国卫生研究院文献>Infection and Immunity >Note: Composition and Gene Expression of the cag Pathogenicity Island in Helicobacter pylori Strains Isolated from Gastric Carcinoma and Gastritis Patients in Costa Rica
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Note: Composition and Gene Expression of the cag Pathogenicity Island in Helicobacter pylori Strains Isolated from Gastric Carcinoma and Gastritis Patients in Costa Rica

机译：注意：从哥斯达黎加的胃癌和胃炎患者中分离出的幽门螺杆菌菌株cag致病岛的组成和基因表达

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摘要

The composition and in vitro expression of the cag pathogenicity island genes in a group of Helicobacter pylori strains obtained from patients suffering from chronic gastritis-associated dyspepsia (n = 26) or gastric carcinoma (n = 17) were analyzed. No significant difference in the distribution of the 10 studied regions was found between the cases and the controls. Nine strains did not harbor any of the selected regions: eight (30.8%) isolated from patients with gastritis only and one (5.9%) from a patient with gastric carcinoma. No association was found between the number of repeated sequences at the 3′ end of the cagA gene or the presence of tyrosine phosphorylation motifs and the clinical origin of the strains. The virB10 homolog gene was the sole gene studied to be significantly expressed more often in cancer strains than in gastritis strains (P = 0.03).
机译：分析了一组得自患有慢性胃炎相关消化不良（n = 26）或胃癌（n = 17）的幽门螺杆菌菌株中cag致病岛基因的组成和体外表达。病例与对照之间的10个研究区域的分布没有显着差异。九个菌株未包含任何选定区域：仅从胃炎患者中分离出八株（30.8％），从胃癌患者中分离出一株（5.9％）。在cagA基因3'端的重复序列数或酪氨酸磷酸化基序的存在与菌株的临床起源之间未发现关联。 virB10同源基因是唯一被证实在癌症菌株中比在胃炎菌株中更频繁表达的基因（P = 0.03）。

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