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首页> 外文期刊>Infection and immunity >Composition and Gene Expression of thecag Pathogenicity Island in Helicobacter pyloriStrains Isolated from Gastric Carcinoma and Gastritis Patients in Costa Rica
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Composition and Gene Expression of thecag Pathogenicity Island in Helicobacter pyloriStrains Isolated from Gastric Carcinoma and Gastritis Patients in Costa Rica

机译：哥斯达黎加胃癌和胃炎患者分离的幽门螺杆菌菌株cag致病岛的组成和基因表达

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摘要

The composition and in vitro expression of the cagpathogenicity island genes in a group of Helicobacter pylori strains obtained from patients suffering from chronic gastritis-associated dyspepsia (n = 26) or gastric carcinoma (n = 17) were analyzed. No significant difference in the distribution of the 10 studied regions was found between the cases and the controls. Nine strains did not harbor any of the selected regions: eight (30.8%) isolated from patients with gastritis only and one (5.9%) from a patient with gastric carcinoma. No association was found between the number of repeated sequences at the 3′ end of the cagA gene or the presence of tyrosine phosphorylation motifs and the clinical origin of the strains. ThevirB10 homolog gene was the sole gene studied to be significantly expressed more often in cancer strains than in gastritis strains (P = 0.03).
机译：慢性胃炎相关消化不良（ n ）患者中幽门螺杆菌株中 cag 致病岛基因的组成及体外表达em> = 26）或胃癌（ n = 17）。病例与对照之间的10个研究区域的分布没有显着差异。九个菌株未包含任何选定区域：仅从胃炎患者中分离出八个菌株（30.8％），从胃癌患者中分离出一个菌株（5.9％）。在 cagA 基因3'末端重复序列的数目或酪氨酸磷酸化基序的存在与菌株的临床起源之间没有关联。研究表明， virB10 同源基因是唯一在癌症菌株中比在胃炎菌株中更频繁表达的基因（ P = 0.03）。

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