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Studies on the mechanism of the self-cure reaction in rats infected with Nippostrongylus brasiliensis

机译:巴西夜蛾感染大鼠自愈反应机制的研究

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摘要

The production of ovalbumin-induced anaphylaxis in rats passively immunized with antiserum to Nippostrongylus brasiliensis produced a significant reduction in their transplanted populations of adult worms compared to: (a) rats which were passively immunized alone, and (b) rats subjected to ovalbumin anaphylaxis alone.This result suggests that the physical changes associated with anaphylaxis facilitated the passage of antibody into the sub-epithelial spaces and intestinal lumen where its effect was specifically directed against the worms.Since in naturally infected rats an intestinal lesion is present, which grossly and microscopically resembles that induced by ovalbumin anaphylaxis, it was concluded that this lesion plays a similar role in the self-cure reaction.
机译:与:(a)单独被动免疫的大鼠,和(b)单独进行卵白蛋白过敏的大鼠相比,接受巴西柔毛夜蛾抗血清被动免疫的大鼠的卵白蛋白诱导的过敏反应的产生大大降低了成虫的移植种群。该结果表明,与过敏反应有关的物理变化促进了抗体进入上皮下腔和肠腔的传递,在这种情况下,抗体的作用专门针对蠕虫。由于在自然感染的大鼠中存在肠道病变,这种病变在肉眼和微观上都存在与卵清蛋白过敏反应所致相似,得出的结论是该病灶在自愈反应中起相似的作用。

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