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首页> 美国卫生研究院文献>Immunology >Differentiation of B lymphocytes in sheep. I. Phenotypic analysis of ileal Peyers patch cells and the demonstration of a precursor population for sIg+ cells in the ileal Peyers patches.
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Differentiation of B lymphocytes in sheep. I. Phenotypic analysis of ileal Peyers patch cells and the demonstration of a precursor population for sIg+ cells in the ileal Peyers patches.

机译：绵羊B淋巴细胞的分化。 I.回肠派伊尔氏斑细胞的表型分析和回肠派伊尔氏斑中sIg +细胞的前体种群的演示。

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The ileal Peyer's patches (IPP) of sheep may be a primary lymphoid organ for b cells since they have a number of important features in common with the bursa of Fabricius of chickens. We have examined the surface phenotype of IPP cells. Approximately 90% to 95% of IPP cells are 'low sIgM+'; that is, they have surface IgM, but in much smaller amounts than peripheral B cells, which are 'high sIgM+'. IPP cells with sIgG or sIgA are very rare. Upon exposure to a tumour promotor, phorbol myristate acetate (PMA), in vitro, low sIgM+ cells differentiated into high sIgM+ cells. The amount of Ia-like antigens on the surface also increased after PMA treatment. Approximately 5% of IPP cells bore no identifiable markers. However, these cells could also be induced into high sIgM+ cells upon exposure to PMA; this may indicate the presence of precursors of sIgM+ cells within the IPP. While PNA (peanut agglutinin) binds strongly to the vast majority of IPP cells, it binds very little, if at all, to B cells obtained from the periphery, unless they have been treated with neuraminidase; this suggests that cells in the B lineage retain their PNA receptors, but that these become masked by sialic acid on mature B cells.
机译：绵羊的回肠派伊尔斑块（IPP）可能是b细胞的主要淋巴器官，因为它们具有许多与鸡法氏囊一样的重要特征。我们已经检查了IPP细胞的表面表型。大约90％至95％的IPP细胞为“低sIgM +”；也就是说，它们具有表面IgM，但数量要比周围的B细胞（高sIgM +）少得多。具有sIgG或sIgA的IPP细胞非常罕见。暴露于肿瘤促进剂醋酸佛波肉豆蔻酸酯（PMA）后，低sIgM +细胞分化为高sIgM +细胞。在PMA处理后，表面上Ia样抗原的量也增加了。大约5％的IPP细胞没有可识别的标记。然而，这些细胞也可能在暴露于PMA后被诱导为高sIgM +细胞。这可能表明IPP中存在sIgM +细胞的前体。虽然PNA（花生凝集素）与绝大多数IPP细胞牢固结合，但除非经过神经氨酸酶处理，否则它与从外周获得的B细胞结合的很少，甚至根本不结合。这表明，B谱系中的细胞保留了其PNA受体，但在成熟的B细胞上被唾液酸掩盖了。

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