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Global Properties of Latent Virus Dynamics Models with Immune Impairment and Two Routes of Infection

机译:具有潜在免疫力和两种感染途径的潜伏病毒动力学模型的全局特性

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摘要

This paper studies the global stability of viral infection models with CTL immune impairment. We incorporate both productively and latently infected cells. The models integrate two routes of transmission, cell-to-cell and virus-to-cell. In the second model, saturated virus–cell and cell–cell incidence rates are considered. The basic reproduction number is derived and two steady states are calculated. We first establish the nonnegativity and boundedness of the solutions of the system, then we investigate the global stability of the steady states. We utilize the Lyapunov method to prove the global stability of the two steady states. We support our theorems by numerical simulations.
机译:本文研究了具有CTL免疫缺陷的病毒感染模型的整体稳定性。我们整合了生产性和潜伏性感染细胞。这些模型整合了两种传播途径,即细胞间和病毒间。在第二种模型中,考虑了饱和病毒-细胞和细胞-细胞的发生率。推导基本再现数并计算两个稳态。我们首先建立系统解的非负性和有界性,然后研究稳态的全局稳定性。我们利用李雅普诺夫方法来证明两个稳态的全局稳定性。我们通过数值模拟来支持我们的定理。

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