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首页> 美国卫生研究院文献>Gut >Comparison of radio-opaque pellets and chromium sesquioxide as inert markers in studies requiring accurate faecal collections.
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Comparison of radio-opaque pellets and chromium sesquioxide as inert markers in studies requiring accurate faecal collections.

机译：在需要精确收集粪便的研究中对不透射线的小球和倍半氧化铬作为惰性标记的比较。

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Radio-opaque pellets (ROP) similar to those currently used to measure gastrointestinal transit time have been compared with chromium sesquioxide to assess their suitability for use as inert markers in the gut. Five healthy subjects took both markers with every meal for two separate three week periods while taking metabolically controlled diets. Overall recovery of both markers was satisfactory; ROP 99.7 +/- 0.3% (SD) and chromium 97.8 +/- 1.6% (SD). A comparison of the amount for each marker recovered in 69 separate faecal collection periods of various lengths showed close agreement (R = 0.99) and the tail-off in marker excretion after cessation of ROP and chromium intake was similar, although slightly more prolonged for chromium. The amount of marker retained in the gut was 13.5% greater for chromium at the end of the three week study periods. Both markers proved satisfactory for correcting variations in faecal calcium output. The ROP, however, offer clear advantages over chromium in that they are considerably easier and quicker to measure, the method of measurement using x-rays does not alter the stools and faecal handling is minimised. The precision of ROP measurement is greater and, because of the variety of ROP available, they offer more flexibility for metabolic studies. In addition, stool by stool analysis is possible enabling simultaneous measurement of mean transit time to be made in experimental subjects.
机译：已将类似于目前用于测量胃肠道通过时间的不透射线小球（ROP）与倍半氧化铬进行了比较，以评估它们是否适合用作肠内惰性标记。五名健康​​受试者在进行代谢控制饮食的同时，每顿饭在两个单独的三周时间内同时服用了两种标志物。两种标记物的总体恢复令人满意。 ROP 99.7 +/- 0.3％（SD）和铬97.8 +/- 1.6％（SD）。在不同长度的69个单独粪便收集期中回收的每种标记物的量进行比较，结果显示出一致性（R = 0.99），并且在停止ROP和铬摄入后，标记物排泄的拖尾相似，尽管铬的延长时间略长。在三周的研究期结束时，保留在肠道中的标记物的铬含量增加了13.5％。两种标记物都证明对纠正粪便钙输出的变化是令人满意的。然而，ROP较铬具有明显的优势，因为它们测量起来相当容易和快捷，使用X射线的测量方法不会改变粪便，并且最大程度地减少了粪便处理。 ROP测量的精度更高，并且由于可用的ROP种类繁多，它们为代谢研究提供了更大的灵活性。另外，可以通过逐粪分析来同时测量实验对象的平均通过时间。

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