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New classification of endometrial cancers: the development and potential applications of genomic-based classification in research and clinical care

机译:子宫内膜癌的新分类:基于基因组的分类在研究和临床护理中的发展及潜在应用

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摘要

Endometrial carcinoma (EC) is the fourth most common cancer in women in the developed world. Classification of ECs by histomorphologic criteria has limited reproducibility and better tools are needed to distinguish these tumors and enable a subtype-specific approach to research and clinical care. Based on the Cancer Genome Atlas, two research teams have developed pragmatic molecular classifiers that identify four prognostically distinct molecular subgroups. These methods can be applied to diagnostic specimens (e.g., endometrial biopsy) with the potential to completely change the current risk stratification systems and enable earlier informed decision making. The evolution of genomic classification in ECs is shared herein, as well as potential applications and discussion of the essential research still needed in order to optimally integrate molecular classification in to current standard of care.
机译:子宫内膜癌(EC)是发达国家女性中第四大最常见的癌症。通过组织形态学标准对EC的分类具有有限的可重复性,并且需要更好的工具来区分这些肿瘤并实现研究和临床护理的亚型特异性方法。基于癌症基因组图谱,两个研究小组开发了实用的分子分类器,可识别四个在预后上不同的分子亚组。这些方法可以应用于诊断标本(例如子宫内膜活检),有可能完全改变当前的风险分层系统并能够更早地做出明智的决策。 EC共享基因组分类的演变,以及潜在的应用和讨论,以便将分子分类最佳地整合到当前的护理标准中,仍然需要进行必要的研究。

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