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首页> 美国卫生研究院文献>Frontiers in Veterinary Science >Heart Rate and Heart Rate Variability of Rhesus Macaques (Macaca mulatta) Affected by Left Ventricular Hypertrophy
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Heart Rate and Heart Rate Variability of Rhesus Macaques (Macaca mulatta) Affected by Left Ventricular Hypertrophy

机译：左心室肥厚对猕猴的心率和心率变异性的影响

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Hypertrophic cardiomyopathy (HCM) is frequently associated with sudden cardiac death, presumably due to the development of malignant arrhythmias. The risk of sudden cardiac death due to HCM has been reported to be predicted by assessing electrocardiographic (ECG) changes including frequencies and complexities of arrhythmias as well as heart rate variability (HRV) as an assessment of autonomic balance. Sudden cardiac death in association with naturally-occurring left ventricular hypertrophy (LVH) has been reported in a colony of rhesus macaques and is under investigation as a potential non-human primate model of human HCM. In the present study, 10 rhesus macaques with LVH and 10 without the signs of LVH confirmed by an echocardiographic examination were recruited for assessing ECG and HRV parameters. ECG morphology on 10-s, 6-lead ECG analysis, and the frequency and complexity of arrhythmias as well as HRV on 20-h ambulatory ECG Holter analyses were assessed. On the standard 10-s 6-lead ECG analysis, P wave and QRS complex duration as well as the QRS complex amplitude were significantly increased in the LVH-affected rhesus macaques compared to control rhesus macaques. Analysis of 20-h Holter monitoring revealed no statistically significant differences in the frequency or the complexity of arrhythmias between the LVH and the control groups. Several HRV parameters were smaller in the LVH group than the control group throughout the majority of Holter recordings showing periods of reduced variability, however, no statistically significant differences were achieved across groups and/or time points. These findings indicate that ECG analysis and Holter monitoring of rhesus macaques are feasible and that ECG morphological changes in association with LVH could be used as a possible component of an antemortem screening tool. The rhesus macaques of this study did not reveal clear indications of risk for sudden cardiac death. Further studies are necessary to determine the etiology of sudden cardiac death due in LVH affected rhesus macaques and identify if any parameters of arrhythmia assessment or HRV can be used to predict the development of sudden cardiac death.
机译：肥厚型心肌病（HCM）通常与心源性猝死有关，大概是由于恶性心律失常的发展。据报道，通过评估心电图（ECG）变化（包括心律不齐的频率和复杂性以及心律变异性（HRV））来评估自主神经平衡，可以预测由于HCM导致心脏猝死的风险。在恒河猴群中，已经报告了与自然发生的左心室肥大（LVH）相关的猝死，目前正在作为人类HCM的潜在非人类灵长类动物模型进行研究。在本研究中，招募了10例具有LVH的恒河猴和10例未经超声心动图检查证实的LVH征象的猕猴来评估ECG和HRV参数。评估了10 s，6导联ECG分析的ECG形态，以及20小时动态ECG Holter分析的心律失常的频率和复杂性以及HRV。在标准的10-s 6导联心电图分析中，与对照组恒河猴相比，受LVH感染的恒河猴的P波和QRS复杂持续时间以及QRS复杂振幅明显增加。对20小时动态心电图监测的分析显示，LVH与对照组之间心律不齐的频率或复杂性无统计学差异。在大部分动态心电图记录中，LVH组的几个HRV参数都比对照组小，显示出变异性降低的时期，但是，各组和/或时间点之间没有统计学上的显着差异。这些发现表明，对恒河猴进行ECG分析和动态心电图监测是可行的，并且与LVH关联的ECG形态学变化可用作前验筛查工具的可能组成部分。这项研究的恒河猴并没有显示出心脏猝死风险的明确迹象。需要进一步的研究来确定在LVH感染的恒河猴中由于心源性猝死的病因，并确定是否有任何心律不齐评估或HRV参数可用于预测心源性猝死的发展。

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