• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Comparative Medicine >Antemortem Screening for Left Ventricular Hypertrophy in Rhesus Macaques (Macaca mulatta)
【24h】

Antemortem Screening for Left Ventricular Hypertrophy in Rhesus Macaques (Macaca mulatta)

机译：猕猴左心室肥大的死前筛查

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Concentric left ventricular hypertrophy (LVH) is a hallmark finding in hypertrophic cardiomyopathy that leads to diastolic dysfunction and variable cardiac consequences as severe as congestive heart failure and sudden cardiac death. LVH was diagnosed postmortem in a large colony of rhesus macaques (Macaca mulatta), but methods to screen and diagnose LVH in living animals are desired. We hypothesized that targeted echocardiography of macaques with a familial association of LVH would yield antemortem LVH diagnoses. We also hypothesized that cardiac biomarker levels would be higher in sudden-death LVH or occult LVH than controls and that cardiac troponin I (cTnI) levels would be higher in macaques housed outdoors than indoors. Sera were assayed for cardiac biomarkers (cTnI, C-reactive protein, creatinine kinase-MB, creatine phosphokinase, and LDH), in conjunction with echocardiography, after diagnosis by postmortem exam or from animals with different levels of exercise due to indoor compared with outdoor housing. None of the investigated biomarkers were associated with LVH. cTnI levels were significantly higher in serum collected from outdoor than indoor macaques. In addition, LVH was diagnosed in 29.4% of subjects with a familial association of LVH. These findings suggest that exercise may increase cTnI levels in rhesus macaques and that targeted echocardiography of rhesus macaques with a familial association of LVH was the most useful variable examined for disease surveillance.
机译：同心左心室肥大（LVH）是肥厚型心肌病的标志性发现，可导致舒张功能障碍和各种心脏后果，如充血性心力衰竭和猝死。 LVH被诊断为在恒河猴（Macaca mulatta）的大菌落中进行死后诊断，但是需要一种在活体动物中筛选和诊断LVH的方法。我们假设以猕猴为目标的超声心动图与LVH家族关联会产生LVH诊断前诊断。我们还假设在突然死亡的LVH或隐匿性LVH中，心脏生物标志物的水平将高于对照组，并且在室外居住的猕猴中的肌钙蛋白I（cTnI）水平将高于室内。在进行死后检查后，或通过室内或室外进行运动水平不同的动物诊断后，结合超声心动图对血清进行心脏生物标志物（cTnI，C反应蛋白，肌酐激酶-MB，肌酸磷酸激酶和LDH）的分析住房。没有调查的生物标志物与LVH相关。从室外猕猴采集的血清中的cTnI水平显着高于室内猕猴。另外，在LVH家族关联中被诊断出LVH的占29.4％。这些发现表明，运动可能会增加猕猴的cTnI水平，而针对猕猴的超声心动图与LVH家族关联是检查疾病监测最有用的变量。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号