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首页> 美国卫生研究院文献>Evidence-based Complementary and Alternative Medicine : eCAM >Evaluation of Bioactive Compounds Pharmaceutical Quality and Anticancer Activity of Curry Leaf (Murraya koenigii L.)
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Evaluation of Bioactive Compounds Pharmaceutical Quality and Anticancer Activity of Curry Leaf (Murraya koenigii L.)

机译：咖喱叶（Murraya koenigii L.）的生物活性化合物药物质量和抗癌活性的评估

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摘要

In this study, we investigated some bioactive compounds and pharmaceutical qualities of curry leaf (Murraya koenigii L.) extracts from three different locations in Malaysia. The highest TF and total phenolic (TP) contents were observed in the extracts from Kelantan (3.771 and 14.371 mg/g DW), followed by Selangor (3.146 and 12.272 mg/g DW) and Johor (2.801 and 12.02 mg/g DW), respectively. High quercetin (0.350 mg/g DW), catechin (0.325 mg/g DW), epicatechin (0.678 mg/g DW), naringin (0.203 mg/g DW), and myricetin (0.703 mg/g DW) levels were observed in the extracts from Kelantan, while the highest rutin content (0.082 mg/g DW) was detected in the leaves from Selangor. The curry leaf extract from Kelantan exhibited higher concentration of gallic acid (0.933 mg/g DW) than that from Selangor (0.904 mg/g DW) and Johor (0.813 mg/g DW). Among the studied samples, the ones from Kelantan exhibited the highest radical scavenging activity (DPPH, 66.41%) and ferric reduction activity potential (FRAP, 644.25 μm of Fe(II)/g) followed by those from Selangor (60.237% and 598.37 μm of Fe(II)/g) and Johor (50.76% and 563.42 μm of Fe(II)/g), respectively. A preliminary screening showed that the curry leaf extracts from all the locations exhibited significant anticarcinogenic effects inhibiting the growth of breast cancer cell line (MDA-MB-231) and maximum inhibition of MDA-MB-231 cell was observed with the curry leaf extract from Kelantan. Based on these results, it is concluded that Malaysian curry leaf collected from the North (Kelantan) might be potential source of potent natural antioxidant and beneficial chemopreventive agents.
机译：在这项研究中，我们调查了来自马来西亚三个不同地点的咖喱叶（Murraya koenigii L.）提取物的一些生物活性化合物和药用品质。吉兰丹提取物中的TF和总酚（TP）含量最高（3.771和14.371 mg / g DW），其次是雪兰莪（3.146和12.272 mg / g DW）和柔佛州（2.801和12.02 mg / g DW） ， 分别。观察到高槲皮素（0.350 mg / g DW），儿茶素（0.325 mg / g DW），表儿茶素（0.678 mg / g DW），柚皮苷（0.203 mg / g DW）和杨梅素（0.703 mg / g DW）水平吉兰丹提取物的含量最高，而雪兰莪州的叶子中芦丁含量最高（0.082μg/ g DW）。吉兰丹州咖喱叶提取物的没食子酸浓度为（0.933 mg / g DW），高于雪兰莪（0.904 mg / g DW）和柔佛州（0.813 mg / g DW）。在研究的样品中，吉兰丹州的样品表现出最高的自由基清除活性（DPPH，66.41％）和铁还原活性电位（FRAP，Fe（II）/ g644.25μm/ g），其次是雪兰莪州的（60.237％和598.37μm） Fe（II）/ g）和柔佛州（Fe（II）/ g分别为50.76％和563.42μm）。初步筛选显示，所有位置的咖喱叶提取物均表现出显着的抗癌作用，可抑制乳腺癌细胞系（MDA-MB-231）的生长，而咖喱叶提取物对MDA-MB-231细胞的抑制作用最大。吉兰丹州。根据这些结果，可以得出结论，从北部（Kelantan）收集的马来西亚咖喱叶可能是有效的天然抗氧化剂和有益的化学预防剂的潜在来源。

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