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首页> 美国卫生研究院文献>Evidence-based Complementary and Alternative Medicine : eCAM >The Effects of Modified Simiao Decoction in the Treatment of Gouty Arthritis: A Systematic Review and Meta-Analysis
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The Effects of Modified Simiao Decoction in the Treatment of Gouty Arthritis: A Systematic Review and Meta-Analysis

机译：加味四妙汤治疗痛风性关节炎的系统评价和荟萃分析

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The modified Simiao decoctions (MSD) have been wildly applied in the treatment of gouty arthritis in China. However, the evidence needs to be evaluated by a systematic review and meta-analysis. After filtering, twenty-four randomised, controlled trials (RCTs) comparing the effects of MSD and anti-inflammation medications and/or urate-lowering therapies in patients with gouty arthritis were included. In comparison with anti-inflammation medications, urate-lowering therapies, or coadministration of anti-inflammation medications and urate-lowering therapies, MSD monotherapy significantly lowered serum uric acid (p < 0.00001, mean difference = −90.62, and 95% CI [−128.38, −52.86]; p < 0.00001, mean difference = −91.43, and 95% CI [−122.38, −60.49]; p = 0.02, mean difference = −40.30, and 95% CI [−74.24, −6.36], resp.). Compared with anti-inflammation medications and/or urate-lowering therapies, MSD monotherapy significantly decreased ESR (p < 0.00001; mean difference = −8.11; 95% CI [−12.53, −3.69]) and CRP (p = 0.03; mean difference = −3.21; 95% CI [−6.07, −0.36]). Additionally, the adverse effects (AEs) of MSD were fewer (p < 0.00001; OR = 0.08; 95% CI [0.05, 0.16]). MSD are effective in the treatment of gouty arthritis through anti-inflammation and lowering urate. However, the efficacy of MSD should be estimated with more RCTs.
机译：改良的四妙汤（MSD）已在中国广泛应用于痛风性关节炎的治疗。但是，需要通过系统的审查和荟萃分析来评估证据。过滤后，包括二十四项随机对照试验（RCT），比较了MSD和抗炎药和/或降低痛风性关节炎患者的疗效。与抗炎药，降低尿酸盐的疗法，或同时服用抗炎药和降低尿酸盐的疗法相比，MSD单一疗法可显着降低血清尿酸（p <0.00001，平均差异= −90.62和95％CI [- 128.38，−52.86]； p <0.00001，平均差异= −91.43，95％CI [−122.38，-60.49]； p = 0.02，平均差异= −40.30，95％CI [−74.24，−6.36]，分别）。与抗炎药和/或降低尿酸盐的疗法相比，MSD单一疗法显着降低了ESR（p <0.00001；平均差异= −8.11； 95％CI [−12.53，-3.69]）和CRP（p = 0.03；平均差异） = -3.21； 95％CI [-6.07，-0.36]）。此外，MSD的不良反应（AE）更少（p <0.00001； OR = 0.08； 95％CI [0.05，0.16]）。 MSD可通过消炎和降低尿酸来有效治疗痛风性关节炎。但是，应通过更多的RCT来评估MSD的疗效。

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