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首页> 美国卫生研究院文献>European Journal of Translational Myology >Comparison of intradermal Dexmedmotidine and subcutaneous Ketamine for post-surgical pain management in patients with abdominal hysterectomy
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Comparison of intradermal Dexmedmotidine and subcutaneous Ketamine for post-surgical pain management in patients with abdominal hysterectomy

机译：腹膜内子宫切除术患者皮内右美托咪定和皮下氯胺酮治疗术后疼痛的比较

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摘要

Hysterectomy after cesarean section is the second most commonly used surgery for women in the United States. One of the most common problem after hysterectomy is pain. We decided to compare the effects of dexmedmotidine or ketamine on pain in patients by a double blind randomized clinical trial on 126 female candidates for abdominal hysterectomy in three groups of 42 persons referred to Taleghani hospital in Arak. For the first group, 50 micrograms of intradermal dexmedmotidine were injected, while in the second group, patients were injected with 100 mg of subcutaneous ketamine and the third group received 5 cc normal saline. Data were next analyzed by SPSS version 19. The mean age and body mass index of the patients were not significantly different in the three groups. The mean scores of pain during recovery of patients in ketamine, dexmedmotidine and placebo groups were 4.2±0.77, 2.6±0.89 and 1.3±0.87, respectively (p = 0.001). Scores of pain in patients at 4 and 8 hours after surgery showed also significant differences. In conclusion, ketamine and dexmedmotidine significantly reduce the severity of pain, but ketamine has a lower effect.
机译：剖宫产后的子宫切除术是美国女性第二大最常用的手术。子宫切除术后最常见的问题之一是疼痛。我们决定通过一项三盲的随机双盲临床试验，比较右美托咪定或氯胺酮对患者疼痛的影响，该临床试验涉及3组42位转诊至阿拉克塔莱哈尼医院的126名女性进行子宫子宫切除术。对于第一组，皮下注射右美托咪定50毫克，而在第二组中，患者注射100毫克皮下氯胺酮，第三组接受5 cc生理盐水。接下来通过SPSS 19版分析数据。三组患者的平均年龄和体重指数无显着差异。氯胺酮，右美托咪定和安慰剂组患者康复期间的平均疼痛评分分别为4.2±0.77、2.6±0.89和1.3±0.87（p = 0.001）。术后4小时和8小时患者的疼痛分数也显示出显着差异。总之，氯胺酮和右美托咪定可显着减轻疼痛的严重程度，但氯胺酮的作用较低。

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