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首页> 美国卫生研究院文献>European Journal of Radiology Open >Radiological findings of Posterior Reversible Encephalopathy Syndrome in transplanted children previous affected by hemoglobinopathy: A neuroimaging retrospective analysis
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Radiological findings of Posterior Reversible Encephalopathy Syndrome in transplanted children previous affected by hemoglobinopathy: A neuroimaging retrospective analysis

机译：先前受血红蛋白病影响的移植儿童后可逆性脑病综合征的影像学表现：神经影像回顾性分析

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To evaluate, by Magnetic Resonance Imaging, if there is a typical pattern or severity of PRES in transplanted children for hemoglobinopathy. Secondary point was to investigate the pattern and severity of PRES in children with thalassemia-THAL and sickle-cell disease-SCD after autologous hematopoietic stem cell transplantation (aHSCT). Finally, we evaluate the presence of atypical PRES presentation and the involved area of central nervous system. Two neuroradiologists analyzed retrospectively MRI of 21 transplanted children for THAL or SCD treated with CI, with neurological symptoms and signs of PRES. The Bartynski and Boardman classification has been used for PRES pattern while McKinney scale for PRES severity. Fisher Exact Probability test or Chi-square test were used to compare the categorical data. In the 21 transplanted children the PRES severity was typically mild (85.7%) without preferring radiological pattern at MRI. The analysis didn't show significant association between PRES pattern or PRES severity and previous hemoglobinopathy (THAL or SCD). No atypical PRES presentation has been found. PRES severity in transplanted children for hemoglobinopathy is typically mild. Notwithstanding children affected by SCD have a damage on the capillary endothelium, after aHSCT our data didn't show a different PRES severity and pattern than THAL children.
机译：通过磁共振成像来评估移植儿童血红蛋白病是否存在典型的PRES模式或严重程度。次要点是研究自体造血干细胞移植（aHSCT）后地中海贫血-THAL和镰状细胞病-SCD儿童的PRES的类型和严重程度。最后，我们评估了非典型PRES表现的存在和中枢神经系统的受累区域。两名神经放射科医生回顾性分析了21例接受CI治疗的移植儿童的THAL或SCD的MRI，并伴有神经系统症状和PRES体征。 Bartynski和Boardman分类已用于PRES模式，而McKinney量表则用于PRES严重程度。使用Fisher精确概率检验或卡方检验来比较分类数据。在21例移植儿童中，PRES严重程度通常较轻（85.7％），而不喜欢MRI的放射学检查。分析未显示PRES模式或PRES严重程度与既往血红蛋白病（THAL或SCD）之间存在显着关联。找不到非典型的PRES演示文稿。移植儿童血红蛋白病的PRES严重程度通常较轻。尽管受SCD影响的儿童的毛细血管内皮细胞受到损害，但aHSCT后我们的数据并未显示与THAL儿童不同的PRES严重程度和模式。

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