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首页> 美国卫生研究院文献>Endoscopy International Open >CD31-positive microvessel density within adenomas of Lynch Syndrome patients is similar compared to adenomas of non-Lynch patients
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CD31-positive microvessel density within adenomas of Lynch Syndrome patients is similar compared to adenomas of non-Lynch patients

机译：林奇综合征患者的腺瘤内CD31阳性微血管密度与非林奇患者的腺瘤相似

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>Background and study aims  Microsatellite instability accelerates colorectal cancer development in patients with Lynch syndrome (LS). Previous research showed that virtual chromoendoscopy increases detection of adenomas during colonoscopy surveillance of patients with LS. Because previous research revealed that Lynch patients have an increased vascular network in the oral mucosa, we hypothesized that increased vascularization of LS-associated adenomas is the cause of better detection with virtual chromoendoscopy. >Patients and methods  In this pilot study, patients with LS having a proven germline mutation were selected from two tertiary referral hospitals and non-LS patients from an outpatient colonoscopy center. Adenomas from patients with LS were exactly matched in size and histology with adenomas from non-LS patients. Initial adenoma diagnosis was confirmed by a specialist pathologist. All adenomas were stained with CD31 and adenomatous tissue was annotated by the specialist pathologist. Image analysis of CD31-positive microvessel density was conducted using FIJI software. >Results  Colonoscopy of 63 patients with LS and 24 non-LS patients provided 40 adenomas that could be exactly matched in size and histology. In image-analysis, the CD31-positive microvessel density (2.49 % vs. 2.47 %, P  = 0.96), the average size of CD31-positive structures (514 μm 2 vs. 523 μm 2 , P  = 0.26) nor the amount of vascular structures per mm2(183 vs. 176,P = 0.50) differed between adenomas of LS patients and non-Lynch patients.>Conclusion The outcomes of this pilot case-control study did not provide further insights into the mechanism of increased adenoma detection in LS patients using virtual chromoendoscopy techniques.
机译：>背景和研究目的：微卫星不稳定性会加速Lynch综合征（LS）患者的结直肠癌发展。先前的研究表明，在结肠镜检查LS患者期间，虚拟色内窥镜检查可增加腺瘤的检出率。因为先前的研究表明，Lynch患者的口腔黏膜血管网络增加，所以我们假设LS相关腺瘤的血管化增加是通过虚拟内窥镜检查更好的原因。 >患者和方法在该初步研究中，从两家三级转诊医院和门诊结肠镜检查中心的非LS患者中选出具有已证实种系突变的LS患者。 LS患者的腺瘤在大小和组织学上与非LS患者的腺瘤完全匹配。腺瘤的初步诊断由专业病理学家确认。所有腺瘤均用CD31染色，腺瘤组织由专业病理学家标注。使用FIJI软件进行CD31阳性微血管密度的图像分析。 >结果结肠镜检查对63例LS患者和24例非LS患者进行了结肠镜检查，结果显示40例腺瘤的大小和组织学可以完全匹配。在图像分析中，CD31阳性微血管密度（2.49％vs. 2.47％，P = 0.96），CD31阳性结构的平均大小（514μm 2 与523μm 2 ，P = 0.26）或每毫米的血管结构数量 2 （183比176，PLS患者和非Lynch患者的腺瘤之间的差异为0.50）。>结论这项先导病例对照研究的结果并未提供进一步了解使用虚拟色内窥镜检查技术检查LS患者腺瘤增加的机制。

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