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首页> 外文期刊>Endoscopy International Open >CD31-positive microvessel density within adenomas of Lynch Syndrome patients is similar compared to adenomas of non-Lynch patients
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CD31-positive microvessel density within adenomas of Lynch Syndrome patients is similar compared to adenomas of non-Lynch patients

机译：与非林奇患者的腺瘤相比，CD31阳性微血管密度在林奇综合征患者的腺瘤内相似

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Background and study aims Microsatellite instability accelerates colorectal cancer development in patients with Lynch syndrome (LS). Previous research showed that virtual chromoendoscopy increases detection of adenomas during colonoscopy surveillance of patients with LS.?Because previous research revealed that Lynch patients have an increased vascular network in the oral mucosa, we hypothesized that increased vascularization of LS-associated adenomas is the cause of better detection with virtual chromoendoscopy. Patients and methods In this pilot study, patients with LS having a proven germline mutation were selected from two tertiary referral hospitals and non-LS patients from an outpatient colonoscopy center. Adenomas from patients with LS were exactly matched in size and histology with adenomas from non-LS patients. Initial adenoma diagnosis was confirmed by a specialist pathologist. All adenomas were stained with CD31 and adenomatous tissue was annotated by the specialist pathologist. Image analysis of CD31-positive microvessel density was conducted using FIJI software. Results Colonoscopy of 63 patients with LS and 24 non-LS patients provided 40 adenomas that could be exactly matched in size and histology. In image-analysis, the CD31-positive microvessel density (2.49?% vs. 2.47?%, P =?0.96), the average size of CD31-positive structures (514?μmsup2/sup vs. 523?μmsup2/sup, P =?0.26) nor the amount of vascular structures per mmsup2/sup (183 vs. 176, P =?0.50) differed between adenomas of LS patients and non-Lynch patients. Conclusion The outcomes of this pilot case-control study did not provide further insights into the mechanism of increased adenoma detection in LS patients using virtual chromoendoscopy techniques. sup*/sup These authors contributed equally.
机译：背景和研究目的是微卫星不稳定性在林奇综合征（LS）患者中加速结直肠癌发育。以前的研究表明，虚拟微型镜检查增加了LS的患者的结肠镜检查期间对腺瘤的检测。据前则揭示了林奇患者在口腔粘膜中有血管网络增加，我们假设LS相关的腺瘤的血管形成增加是原因更好地检测虚拟色解镜检查。在该试点研究中的患者和方法，LS患者具有经过验证的种系突变的患者，选自来自外部结肠镜检查中心的两位高等教育医院和非LS患者。 LS患者的腺瘤与来自非LS患者的腺瘤的大小和组织学相匹配。初始腺瘤诊断由专业病理学家确认。所有腺瘤均用CD31染色，腺瘤组织被专科病理学家注释。斐济软件进行了CD31阳性微血管密度的图像分析。结果63例LS和24例非LS患者的结肠镜检查提供40例腺瘤，其尺寸和组织学均完全匹配。在图像分析中，CD31阳性微血管密度（2.49？％与2.47？％，P = 0.96），CD31阳性结构的平均尺寸（514？μm 2 与523 ？μm 2 ，p = 0.26），或每mm 2 （183 vs.176，p = 0.50）的血管结构的量不同于LS患者的腺瘤和非林奇患者。结论该试点案例对照研究的结果未提供进一步的见解，进一步了解使用虚拟透视技术LS患者增加腺瘤检测的机制。 * 这些作者平均贡献。

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