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A Study of the Antioxidant Effect of Alpha Lipoic Acids on Sperm Quality

机译：α-硫辛酸对精子质量的抗氧化作用研究

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摘要

OBJECTIVEAssisted reproductive techniques are useful in helping infertile couples achieve successful conception. Initial studies have shown that sperm cryopreservation, one step in assisted reproduction, causes a dramatic reduction in sperm quality. This has been attributed to, among other things, free radical activities. The aim of the present study was to minimize this oxidative attack by adding an antioxidant into the sperm microenvironment. Alpha lipoic acids were selected for this purpose for their efficient free radical scavenging properties and solubility in lipid and aqueous phases.

机译：目的辅助生殖技术可帮助不育夫妇成功成年。初步研究表明，精子冷冻保存是辅助生殖的一个步骤，会导致精子质量急剧下降。除其他外，这归因于自由基活动。本研究的目的是通过在精子微环境中添加抗氧化剂来最大程度地减少这种氧化攻击。为此选择α硫辛酸是因为它们具有有效的自由基清除性能以及在脂质和水相中的溶解度。

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期刊名称 Clinics
作者
Siti Fatimah Ibrahim; Khairul Osman; Srijit Das; Abas Mazni Othman; Norzaiti Abdul Majid; Mohd Padzil Abdul Rahman;
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作者单位

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年(卷),期 2008(63),4
年度 2008
页码 545–550
总页数 6
原文格式 PDF
正文语种
中图分类基础医学;
关键词
Sperm Semen Action Antioxidant Oxidative stress Alpha lipoic acids Analysis;

机译：精子;精液;作用;抗氧化剂;氧化应激;硫辛酸;分析;

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专利

1. A study of the antioxidant effect of alpha lipoic acids on sperm quality [J] . Abas Mazni Othman, Khairul Osman, Mohd Padzil Abdul Rahman, Clinics . 2008,第4期

机译：α-硫辛酸对精子质量的抗氧化作用研究
2. Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid: a 7-month multicenter randomized controlled trial (ALADIN III Study). ALADIN III Study Group. Alpha-Lipoic Acid in Diabetic Neuropathy. [J] . Ziegler D, Hanefeld M, Ruhnau KJ, Diabetes care . 1999,第8期

机译：抗氧化剂α-硫辛酸治疗有症状的糖尿病多发性神经病：一项为期7个月的多中心随机对照试验（ALADIN III研究）。 ALADIN III研究组。糖尿病神经病中的α-硫辛酸。
3. Antioxidant action of alpha lipoic acid on the testis and epididymis of diabetic rats: morphological, sperm and immunohistochemical evaluation [J] . Corrêa Lanna Beatriz Neves Silva, Costa Carlos Alberto Soares da, Ribas José Ant?nio Silva, International braz j urol . 2019,第4期

机译：α硫辛酸对糖尿病大鼠睾丸和附睾的抗氧化作用：形态，精子和免疫组化评价
4. Sperm quality after swim up and density gradient centrifugation sperm preparation with supplementation of alpha lipoic acid (ALA): A preliminary study [C] . Silvia W. Lestari, Sarah H. Lestari, Dwi A. Pujianto International Symposium of Biomedical Engineering . 2018

机译：游泳后的精子质量和密度梯度离心精子制备，用α硫辛酸（ALA）：初步研究
5. Antioxidant mechanisms of ascorbate and (R)-alpha-lipoic acid in aging and transition metal ion-mediated oxidative stress. [D] . Suh, Jung Hyuk. 2004

机译：抗坏血酸和（R）-α-硫辛酸在老化和过渡金属离子介导的氧化应激中的抗氧化机理。
6. Does alpha-lipoic acid–loaded nanostructured lipid carriers improve post-thawed sperm quality and ameliorate apoptosis-related genes of rooster sperm? [O] . Abouzar Najafi, Hossein Daghigh Kia, Hamed Hamishehkar 2021

机译：α-硫辛酸负载的纳米结构脂质载体是否改善了雄鸡精子的解冻后的精子质量和改善凋亡相关基因？
7. A Study of the Antioxidant Effect of Alpha Lipoic Acids on Sperm Quality [O] . Ibrahim, Siti Fatimah, Osman, Khairul, Das, Srijit, 2008

机译：α-硫辛酸对精子质量的抗氧化作用研究

A Study of the Antioxidant Effect of Alpha Lipoic Acids on Sperm Quality

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