Graft-to-Recipient Weight Ratio Associated With Tacrolimus Metabolism Following Pediatric Living Donor Liver Transplantations

机译：小儿活体供体肝移植后与他克莫司代谢相关的移植物与受体重量比

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OBJECTIVESTacrolimus (TAC) is an important immunosuppressant in liver transplantation. Since TAC is mainly metabolized by the liver enzymes CYP3A4 and 5, liver function is crucial for its pharmacokinetics (PK). Liver function is dynamic after liver transplantation; hence the PK of TAC metabolism after pediatric liver transplantation is not well understood. We aimed to investigate the time-dependent changes in TAC metabolism and to find factors influencing TAC PK after pediatric liver transplantation.

机译：目的他克莫司（TAC）是肝移植中一种重要的免疫抑制剂。由于TAC主要由肝酶CYP3A4和5代谢，因此肝功能对其药代动力学（PK）至关重要。肝移植后肝功能是动态的；因此，对小儿肝移植后TAC代谢的PK知之甚少。我们旨在调查TAC代谢的时间依赖性变化，并寻找影响小儿肝移植后TAC PK的因素。

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期刊名称 The Journal of Pediatric Pharmacology and Therapeutics : JPPT
作者
Kensuke Shoji; Isao Miyairi; Eisuke Inoue; Akinari Fukuda; Seisuke Sakamoto; Mureo Kasahara;
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作者单位

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年(卷),期 2019(24),2
年度 2019
页码 138–147
总页数 10
原文格式 PDF
正文语种
中图分类药学;
关键词
children concentration-dose ratio immunosuppressant liver function tacrolimus time-dependent change;

机译：儿童;剂量-剂量比;免疫抑制剂;肝功能;他克莫司;时间依赖性变化;

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专利

1. Graft-to-Recipient Weight Ratio Threshold Adjusted to the Model for End-Stage Liver Disease Score for Living Donor Liver Transplantation [J] . Alim Altan, Erdogan Yalcin, Yuzer Yildiray, Liver transplantation: official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society . 2016,第12期

机译：活体供体肝移植终末期肝病评分模型调整的移植物与收件人的体重比阈值
2. Excellent Perioperative and Long-Term Outcomes with Lower Graft-to-Recipient Weight Ratio for Living Donor Liver Transplantation [J] . Wong Tiffany, Ng Kelvin K. C., Fung James Yan Yue, Transplantation: Official Journal of the Transplantation Society . 2018,第9Suppla期

机译：优异的围手术期和长期成果，具有较低的植入物肝移植的接受者对受体重量比
3. How far can we lower graft-to-recipient weight ratio for living donor liver transplantation under modulation of portal venous pressure? [J] . Uemura Tadahiro, Wada Seidai, Kaido Toshimi, Surgery . 2016,第6期

机译：在门静脉压力的调节下，我们可以降低活体供肝移植的移植物与受体的重量比多大？
4. Liver regeneration after living donor partial liver transplantation [C] . Kenichi Hakamada, Shunji Narumi, Kageyoshi Seino, Hirosaki Transplantation Research Project . 2000

机译：活体部分肝移植后的肝脏再生
5. Splenectomy in living donor liver transplantation and risk factors of portal vein thrombosis [D] . Kurata Nobuhiko, 倉田信彦 2019

机译：活体供体肝脾切除术及门静脉血栓形成的危险因素
6. An appraisal of pediatric liver transplantation from living relatives. Initial clinical experiences in 20 pediatric liver transplantations from living relatives as donors. [O] . K Ozawa, S Uemoto, K Tanaka, 1992

机译：在世亲属对小儿肝移植的评估。活着的亲戚作为捐献者进行20例小儿肝移植的初步临床经验。
7. Zero mortality using graft-to-recipient weight ratio less than 0.6 in adult living donor liver transplantation: overcoming small-for-size syndrome [O] . Tiffany CL. Wong, Kelvin Ng, Jeff Dai, 2019

机译：在成人活体供体肝移植中使用接枝到受体重量比零死亡率小于0.6％：克服小于大小的综合症

Graft-to-Recipient Weight Ratio Associated With Tacrolimus Metabolism Following Pediatric Living Donor Liver Transplantations

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