• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>PLoS Computational Biology >Comparisons of Allergenic and Metazoan Parasite Proteins: Allergy the Price of Immunity
【2h】

Comparisons of Allergenic and Metazoan Parasite Proteins: Allergy the Price of Immunity

机译：过敏原和后生寄生虫蛋白的比较：过敏免疫的价格

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Allergic reactions can be considered as maladaptive IgE immune responses towards environmental antigens. Intriguingly, these mechanisms are observed to be very similar to those implicated in the acquisition of an important degree of immunity against metazoan parasites (helminths and arthropods) in mammalian hosts. Based on the hypothesis that IgE-mediated immune responses evolved in mammals to provide extra protection against metazoan parasites rather than to cause allergy, we predict that the environmental allergens will share key properties with the metazoan parasite antigens that are specifically targeted by IgE in infected human populations. We seek to test this prediction by examining if significant similarity exists between molecular features of allergens and helminth proteins that induce an IgE response in the human host. By employing various computational approaches, 2712 unique protein molecules that are known IgE antigens were searched against a dataset of proteins from helminths and parasitic arthropods, resulting in a comprehensive list of 2445 parasite proteins that show significant similarity through sequence and structure with allergenic proteins. Nearly half of these parasite proteins from 31 species fall within the 10 most abundant allergenic protein domain families (EF-hand, Tropomyosin, CAP, Profilin, Lipocalin, Trypsin-like serine protease, Cupin, BetV1, Expansin and Prolamin). We identified epitopic-like regions in 206 parasite proteins and present the first example of a plant protein (BetV1) that is the commonest allergen in pollen in a worm, and confirming it as the target of IgE in schistosomiasis infected humans. The identification of significant similarity, inclusive of the epitopic regions, between allergens and helminth proteins against which IgE is an observed marker of protective immunity explains the ‘off-target’ effects of the IgE-mediated immune system in allergy. All these findings can impact the discovery and design of molecules used in immunotherapy of allergic conditions.
机译：过敏反应可被视为对环境抗原的适应不良性IgE免疫反应。有趣的是，观察到这些机制与在哺乳动物宿主中获得重要程度的抗后生寄生虫（蠕虫和节肢动物）免疫的机制非常相似。基于假说，IgE介导的免疫反应在哺乳动物中进化，从而提供了对后生寄生虫的额外保护，而不是引起过敏，我们预测环境过敏原将与被IgE特异性靶向的后生寄生虫抗原共享关键特性。人口。我们试图通过检查在人类宿主中诱导IgE反应的过敏原和蠕虫蛋白的分子特征之间是否存在显着相似性，来检验这一预测。通过采用各种计算方法，从蠕虫和寄生节肢动物的蛋白质数据集中搜索了2712种独特的IgE抗原蛋白质分子，从而获得了2445种寄生虫蛋白质的全面列表，这些蛋白质在序列和结构上与过敏性蛋白质表现出显着的相似性。这些来自31个物种的寄生虫蛋白中近一半属于10个最丰富的变应原性蛋白结构域家族（EF-hand，Tropomyosin，CAP，Profilin，Lipocalin，胰蛋白酶样丝氨酸蛋白酶，Cupin，BetV1，Expansin和Prolamin）。我们在206种寄生虫蛋白中鉴定了类似表位的区域，并提出了植物蛋白（BetV1）的第一个实例，该蛋白是蠕虫中花粉中最常见的过敏原，并确认它是血吸虫病感染人类中IgE的靶标。识别过敏原和蠕虫蛋白之间的显着相似性（包括表位区域），针对IgE观察到的保护性免疫标志物可证明其是过敏反应中IgE介导的免疫系统的“脱靶”效应。所有这些发现都可能影响用于过敏性疾病免疫治疗的分子的发现和设计。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号