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Effect of intensive insulin treatment on plasma levels of lipoprotein-associated phospholipase A2 and secretory phospholipase A2 in patients with newly diagnosed type 2 diabetes

机译:强化胰岛素治疗对初诊2型糖尿病患者血浆脂蛋白相关磷脂酶A2和分泌型磷脂酶A2的影响

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摘要

BackgroundChina has the highest absolute disease burden of diabetes worldwide. For diabetic patients, diabetes-related vascular complications are major causes of morbidity and mortality. The roles of lipoprotein-associated phospholipase A2 (Lp-PLA2) and secretory phospholipase A2 (sPLA2) as inflammatory markers have been recently evaluated in the pathogenesis of both diabetes and atherosclerosis. We aimed to determine the mechanism through which patients with newly diagnosed type 2 diabetes gain long-term vascular benefit from intensive insulin therapy by evaluating the change in Lp-PLA2 and sPLA2 levels after early intensive insulin treatment and its relevance with insulin resistance and pancreatic β-cell function.
机译:背景中国是世界上糖尿病绝对疾病负担最高的国家。对于糖尿病患者,与糖尿病相关的血管并发症是发病率和死亡率的主要原因。最近已在糖尿病和动脉粥样硬化的发病机理中评估了脂蛋白相关的磷脂酶A2(Lp-PLA2)和分泌型磷脂酶A2(sPLA2)作为炎性标记的作用。我们旨在通过评估早期强化胰岛素治疗后Lp-PLA2和sPLA2水平的变化及其与胰岛素抵抗和胰腺β的相关性,确定新诊断为2型糖尿病的患者从强化胰岛素治疗中获得长期血管益处的机制。 -cell功能。

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