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首页> 美国卫生研究院文献>Middle East Journal of Digestive Diseases >Clinical and Pathological Features of Ulcerative Colitis in Patients with and without Clostridium Difficile Infection; An Observational Study
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Clinical and Pathological Features of Ulcerative Colitis in Patients with and without Clostridium Difficile Infection; An Observational Study

机译：合并和不合并艰难梭菌感染的溃疡性结肠炎的临床和病理特征；观察研究

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BACKGROUND A dramatic rise in the rate of clostridium difficile infection (CDI) in patients with inflammatory bowel disease (IBD) has been reported in recent years. METHODS In this observational case control study, 65 patients were included and were divided into two groups of IBD + CDI as case group and IBD without CDI as control group. RESULTS 35 patients who had positive test for clostridium difficile were assigned to the case group. The control group consisted of 30 patients with negative test for clostridium difficile. Pancolitis was seen in the cases more statistically significant than the controls and proctitis was seen more among the controls than the cases (p = 0.001). The cases were on immunosuppressive (p = 0.001) and antibiotic (p = 0.02) therapy more than the controls. Colonoscopic findings revealed more severe and extensive inflammation among the cases versus milder inflammation among the controls, but these differences were not statistically significant (p = 0.2). Colectomy was seen in 10% of controls and none of the cases and this difference was statistically significant (p value = 0.05). More fecal calprotectin were seen among the cases than the controls and this difference was statistically significant (p < 0.05) CONCLUSION This study showed more clostridium difficile infection among the patients on antibiotic or immunosuppressive therapy. Pathological investigation revealed more severe and extensive inflammation among the cases than the controls. Cases had clinically more severe signs and symptoms with higher mayo scores than the controls. ESR (Erythrocyte sedimentation rate) and fecal calprotectin were higher in patients with positive clostridium difficile infection and serum albumin was lower in such patients.
机译：背景技术近年来，已经报道了炎性肠病（IBD）患者中艰难梭菌感染率（CDI）的急剧增加。方法在该观察性病例对照研究中，纳入65例患者，将其分为两组，IBD + CDI作为病例组，IBD + CDI作为对照组。结果35例艰难梭菌检测呈阳性的患者被纳入病例组。对照组由30例艰难梭菌阴性试验患者组成。在病例中，发现胰腺炎比对照组更具有统计学意义，而在对照组中，直肠炎比病例中更多（p = 0.001）。与对照组相比，这些患者接受了免疫抑制（p = 0.001）和抗生素（p = 0.02）治疗。结肠镜检查结果显示，与对照组相比，炎症较重，炎症较严重，但差异无统计学意义（p = 0.2）。在10％的对照组中未见结肠切除术，在所有病例中均未见，这一差异具有统计学意义（p值= 0.05）。在这些病例中，粪便钙卫蛋白的含量高于对照组，并且该差异具有统计学意义（p <0.05）。结论本研究表明，接受抗生素或免疫抑制治疗的患者中艰难梭菌感染的发生率更高。病理调查显示，与对照组相比，病例中的炎症更为严重和广泛。病例的临床症状和体征均较对照组高，蛋黄酱评分更高。艰难梭菌感染阳性患者的ESR（红细胞沉降率）和粪便钙卫蛋白较高，而血清白蛋白则较低。

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