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Plasticity in expression of the glutamate transporters GLT-1 and GLAST in spinal dorsal horn glial cells following partial sciatic nerve ligation

机译：坐骨神经部分结扎后脊髓背角神经胶质细胞谷氨酸转运蛋白GLT-1和GLAST表达的可塑性

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BackgroundClearance of synaptically released glutamate, and hence termination of glutamatergic neurotransmission, is carried out by glutamate transporters, most especially glutamate transporter-1 (GLT-1) and the glutamate-aspartate transporter (GLAST) that are located in astrocytes. It is becoming increasingly well appreciated that changes in the function and expression of GLT-1 and GLAST occur under different physiological and pathological conditions. Here we investigated the plasticity in expression of GLT-1 and GLAST in the spinal dorsal horn using immunohistochemistry following partial sciatic nerve ligation (PSNL) in rats.

机译：背景技术通过星形胶质细胞中的谷氨酸转运蛋白，最特别是谷氨酸转运蛋白-1（GLT-1）和谷氨酸-天冬氨酸转运蛋白（GLAST），来清除突触释放的谷氨酸盐，从而终止谷氨酸能神经传递。人们越来越认识到，GLT-1和GLAST的功能和表达发生变化是在不同的生理和病理条件下发生的。在这里，我们使用大鼠局部坐骨神经结扎（PSNL）后的免疫组织化学方法研究了脊髓背角中GLT-1和GLAST表达的可塑性。

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期刊名称 Molecular Pain
作者
Wen-Jun Xin; Han-Rong Weng; Patrick M Dougherty;
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年(卷),期 2009(5),-1
年度 2009
页码 15
总页数 8
原文格式 PDF
正文语种
中图分类神经科学;
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专利

1. Plasticity in expression of the glutamate transporters GLT-1 and GLAST in spinal dorsal horn glial cells following partial sciatic nerve ligation [J] . Wen-Jun Xin, Han-Rong Weng, Patrick M Dougherty Molecular pain . 2009,第1期

机译：坐骨神经部分结扎后脊髓背角神经胶质细胞谷氨酸转运蛋白GLT-1和GLAST表达的可塑性
2. Partial sciatic nerve ligation induces increase in the phosphorylation of extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) in astrocytes in the lumbar spinal dorsal horn and the gracile nucleus. [J] . Ma W, Quirion R Pain. . 2002,第1a2期

机译：坐骨神经部分结扎可诱导腰椎脊髓背角和细小核中星形胶质细胞中胞外信号调节激酶（ERK）和c-Jun N端激酶（JNK）的磷酸化增加。
3. Effect of electrical stimulation of sciatic nerve on synaptic plasticity of spinal dorsal horn and spinal c-fos expression in neonatal, juvenile and adult rats. [J] . Jiang Wu, Qisheng Hu, Deying Huang, Brain research . 2012,第Null期

机译：坐骨神经电刺激对新生，幼年和成年大鼠脊髓背角突触可塑性和脊髓c-fos表达的影响。
4. DURATION OF NERVE ROOT COMPRESSIVE TRAUMA MODULATES THE SUBSEQUENT THERMAL HYPERALGESIA SPINAL EXPRESSION OF THE GLUTAMATE TRANSPORTER, GLT1 [C] . Kristen J. Nicholson, Taylor M. Gilliland, Beth A. Winkelstein ASME bioengineering conference . 2014

机译：神经根压迫性创伤的持续时间可调节继发性热痛觉过敏和谷氨酸转运蛋白GLT1的脊髓表达
5. GABAB receptor expression, function, and trafficking in the dorsal horn of the spinal cord and dorsal root ganglia. [D] . Engle, Mitchell Philip. 2007

机译：GABA B受体在脊髓背角和背根神经节中的表达，功能和运输。
6. A toll-like receptor 9 antagonist restores below-level glial glutamate transporter expression in the dorsal horn following spinal cord injury [O] . Alexandra Pallottie, Ayomi Ratnayake, Li Ni, -1

机译：Toll样受体9拮抗剂恢复脊髓损伤后背角中神经胶质谷氨酸转运蛋白的表达
7. Plasticity in Expression of the Glutamate Transporters GLT-1 and GLAST in Spinal Dorsal Horn Glial Cells following Partial Sciatic Nerve Ligation [O] . Wen-Jun Xin, Han-Rong Weng, Patrick M Dougherty 2009

机译：部分坐骨神经结扎后脊髓背角胶质细胞谷氨酸转运蛋白GLT-1和GLAST表达的可塑性

Plasticity in expression of the glutamate transporters GLT-1 and GLAST in spinal dorsal horn glial cells following partial sciatic nerve ligation

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