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Substitutions of Fluorine Atoms and Phenoxy Groups in the Synthesis of Quinoxaline 14-di-N-oxide Derivatives

机译：喹喔啉14-二-N-氧化物衍生物的合成中氟原子和苯氧基的取代

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摘要

The unexpected substitution of fluorine atoms and phenoxy groups attached to quinoxaline or benzofuroxan rings is described. The synthesis of 2-benzyl- and 2-phenoxy-3-methylquinoxaline 1,4-di-N-oxide derivatives was based on the classical Beirut reaction. The tendency of fluorine atoms linked to quinoxaline or benzofuroxan rings to be replaced by a methoxy group when dissolved in an ammonia saturated solution of methanol was clearly demonstrated. In addition, 2-phenoxyquinoxaline 1,4-di-N-oxide derivatives became 2-aminoquinoxaline 1,4-di-N-oxide derivatives in the presence of gaseous ammonia.

机译：描述了连接到喹喔啉或苯并呋喃环上的氟原子和苯氧基的意外取代。 2-苄基和2-苯氧基-3-甲基喹喔啉1,4-二-N-氧化物衍生物的合成基于经典的贝鲁特反应。当溶解在甲醇的氨饱和溶液中时，清楚地表明了连接在喹喔啉或苯并呋喃环上的氟原子被甲氧基取代的趋势。另外，在气态氨的存在下，2-苯氧基喹喔啉1，4-二-N-氧化物衍生物变为2-氨基喹喔啉1，4-二-N-氧化物衍生物。

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期刊名称 Molecules
作者
Esther Vicente; Raquel Villar; Asunción Burguete; Beatriz Solano; Saioa Ancizu; Silvia Pérez-Silanes; Ignacio Aldana; Antonio Monge;
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作者单位

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年(卷),期 2008(13),1
年度 2008
页码 86–95
总页数 10
原文格式 PDF
正文语种
中图分类分子生物学;
关键词
Quinoxaline N-oxides Beirut reaction gaseous ammonia.;

机译：喹喔啉;N-氧化物;贝鲁特反应;氨气。;

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专利

1. Substitutions of Fluorine Atoms and Phenoxy Groups in the Synthesis of Quinoxaline 1,4-di-N-oxide Derivatives† [J] . Ignacio Aldana Molecules . 2008,第1期

机译：喹喔啉1,4-二-N-氧化物衍生物的合成中氟原子和苯氧基的取代†
2. Synthesis and photovoltaic properties of an alternating polymer based fluorene and fluorine substituted quinoxaline derivatives [J] . Haimei Wu, Bo Qu, Di Tian, Reactive & Functional Polymers . 2013,第11期

机译：芴和氟取代的喹喔啉衍生物交替聚合物的合成和光电性能
3. A SIMPLE MEANS OF PREPARING QUINOXALINE DERIVATIVES: DIRECT INTRODUCTION OF C-NUCLEOPHILES INTO THE QUINOXALINE NUCLEUS BY SUBSTITUTING A HYDROGEN ATOM [J] . Yu. A. Azev, E. D. Oparina, B. V. Golomolzin, Pharmaceutical Chemistry Journal . 2013,第3期

机译：制备喹喔啉衍生物的简单方法：通过取代氢原子将C-核素直接引入喹喔啉核中
4. Synthesis and Characterization of 7 - (3 - (substituted-phenoxy) propoxy) Quinazoline Derivatives [C] . YAN He-ping, OUYANG Gui-ping International Conference on Chemical Engineering and Advanced Materials . 2013

机译：7 - （三（取代苯氧基）丙氧基）喹唑啉衍生物的合成与表征
5. I. SYNTHETIC APPROACHES TO SUBSTITUTED 2-OXABICYCLO(3.2.1)OCTANE DERIVATIVES AND II. THE SYNTHESIS OF 1-SUBSTITUTED DERIVATIVES OF ANHYDRO (3-CHLOROACETYL-2-HYDROXYIMIDAZO(1,2-A)PYRIDINIUM HYDROXIDE). [D] . FRIEDMAN, ALAN E. 1973

机译：I.取代2-氧杂双环（3.2.1）正己烷衍生物的合成方法和II。合成1-取代的酸酐（3-氯乙酰基-2-羟基咪唑并（1,2-A）吡啶鎓氢氧化物）。
6. Synthesis and Biological Evaluation of 3-Aryl-quinoxaline-2-carbonitrile 14-Di-N-oxide Derivatives as Hypoxic Selective Anti-tumor Agents [O] . Yunzhen Hu, Qing Xia, Shihao Shangguan, 2012

机译：3-芳基喹喔啉-2-腈14-二-N-氧化物衍生物的合成及其生物评价作为低氧选择性抗肿瘤药
7. Substitutions of fluorine atoms and phenoxy groups in the synthesis of quinoxaline 1,4-di-N-oxide derivatives. [O] . Vicente, E. (Esther), Villar, R. (Raquel), Burguete, A. (Asunción), 2008

机译：喹喔啉1,4-二-N-氧化物衍生物的合成中氟原子和苯氧基的取代。

Substitutions of Fluorine Atoms and Phenoxy Groups in the Synthesis of Quinoxaline 14-di-N-oxide Derivatives

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