A SIMPLE MEANS OF PREPARING QUINOXALINE DERIVATIVES: DIRECT INTRODUCTION OF C-NUCLEOPHILES INTO THE QUINOXALINE NUCLEUS BY SUBSTITUTING A HYDROGEN ATOM

Yu. A. Azev; E. D. Oparina; B. V. Golomolzin; O. S. Ermakova; V. S. Bakulev

首页> 外文期刊>Pharmaceutical Chemistry Journal >A SIMPLE MEANS OF PREPARING QUINOXALINE DERIVATIVES: DIRECT INTRODUCTION OF C-NUCLEOPHILES INTO THE QUINOXALINE NUCLEUS BY SUBSTITUTING A HYDROGEN ATOM

【24h】

A SIMPLE MEANS OF PREPARING QUINOXALINE DERIVATIVES: DIRECT INTRODUCTION OF C-NUCLEOPHILES INTO THE QUINOXALINE NUCLEUS BY SUBSTITUTING A HYDROGEN ATOM

机译：制备喹喔啉衍生物的简单方法：通过取代氢原子将C-核素直接引入喹喔啉核中

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Unsubstituted quinoxaline (I) reacts with dimedone, indanedione, and l-phenyl-3-methylpyrazol-5-one in dimethylsulfoxide in the presence of acid to form monosubstitution products II - IV. Quinoxaline reacts with 1,3-dimethylbarbituric acid in dimethylsulfoxide solution at room temperature to form monosubstitution product V without external catalysis. Heating of I with resorcinol in ethanol in the presence of acid produced resorcinol derivative VI. In the presence of base, quinoxaline reacts with l-phenyl-3-methylpyrazol-5-one to form dipyrazolylmethane VII and tetrapyrazolylethane derivative VIII. Compound VIII undergoes cleavage to form dipyrazolylmethane VII in dimethylformamide solution with boiling or in the presence of iodine at room temperature.

机译：在酸的存在下，未取代的喹喔啉（Ⅰ）在二甲基亚砜中与二甲酮，茚二酮和1-苯基-3-甲基吡唑-5-酮反应形成单取代产物Ⅱ-Ⅳ。喹喔啉在室温下与1，3-二甲基巴比妥酸在二甲基亚砜溶液中反应，形成单取代产物V，而无需外部催化。在酸存在下将I与间苯二酚在乙醇中加热产生间苯二酚衍生物VI。在碱的存在下，喹喔啉与1-苯基-3-甲基吡唑-5-酮反应形成二吡唑基甲烷VII和四吡唑基乙烷衍生物VIII。化合物VIII在沸腾下或在碘的存在下于室温下，在二甲基甲酰胺溶液中裂解形成二吡唑基甲烷VII。

著录项

来源
《Pharmaceutical Chemistry Journal》 |2013年第3期|共4页
作者
Yu. A. Azev; E. D. Oparina; B. V. Golomolzin; O. S. Ermakova; V. S. Bakulev;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类药学;
关键词
quinoxaline; reactions with nucleophiles.;

机译：喹喔啉;与亲核试剂的反应;

相似文献

外文文献
中文文献
专利

1. A SIMPLE MEANS OF PREPARING QUINOXALINE DERIVATIVES: DIRECT INTRODUCTION OF C-NUCLEOPHILES INTO THE QUINOXALINE NUCLEUS BY SUBSTITUTING A HYDROGEN ATOM [J] . Yu. A. Azev, E. D. Oparina, B. V. Golomolzin, Pharmaceutical Chemistry Journal . 2013,第3期

机译：制备喹喔啉衍生物的简单方法：通过取代氢原子将C-核素直接引入喹喔啉核中
2. Substitutions of Fluorine Atoms and Phenoxy Groups in the Synthesis of Quinoxaline 1,4-di-N-oxide Derivatives† [J] . Ignacio Aldana Molecules . 2008,第1期

机译：喹喔啉1,4-二-N-氧化物衍生物的合成中氟原子和苯氧基的取代†
3. General asymmetric hydrogenation of 2-alkyl- and 2-aryl-substituted quinoxaline derivatives catalyzed by iridium-difluorphos: Unusual halide effect and synthetic application [J] . Cartigny D., Berhal F., Nagano T., The Journal of Organic Chemistry . 2012,第10期

机译：铱-二氟膦催化的2-烷基和2-芳基取代的喹喔啉衍生物的一般不对称加氢：异常的卤化物作用和合成应用
4. Composite Membrane of Zirconium Sulfate -Poly(Ether Sulfone Quinoxalines) for Hydrogen and Direct Methanol Fuel Cells [C] . J. Sutrisno, I. Pramudya, A. Latief, Meeting of the Electrochemical Society . 2013

机译：硫酸锆 - 聚氯乙酯（醚砜喹喔啉）的复合膜用于氢和直接甲醇燃料电池
5. SUBSTITUTED QUINOXALINES. [D] . MCLAUGHLIN, ASTLEY RUDYARD. 1981

机译：取代的喹诺酮类。
6. Substitutions of Fluorine Atoms and Phenoxy Groups in the Synthesis of Quinoxaline 14-di-N-oxide Derivatives [O] . Esther Vicente, Raquel Villar, Asunción Burguete, 2008

机译：喹喔啉14-二-N-氧化物衍生物的合成中氟原子和苯氧基的取代
7. A simple means of preparing quinoxaline derivatives: Direct introduction of C-nucleophiles into the quinoxaline nucleus by substituting a hydrogen atom [O] . Azev, Yu. A., Oparina, E. D., Golomolzin, B. V., 2013

机译：制备喹喔啉衍生物的简单方法：通过取代氢原子将C-亲核试剂直接引入喹喔啉核中

A SIMPLE MEANS OF PREPARING QUINOXALINE DERIVATIVES: DIRECT INTRODUCTION OF C-NUCLEOPHILES INTO THE QUINOXALINE NUCLEUS BY SUBSTITUTING A HYDROGEN ATOM

摘要

著录项

相似文献

相关主题

期刊订阅