首页> 美国卫生研究院文献>Neuro-Oncology >Tumour Treating Fields (TTFields) have anti-proliferative effects on paediatric brain tumour cell lines at clinically deliverable field settings
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Tumour Treating Fields (TTFields) have anti-proliferative effects on paediatric brain tumour cell lines at clinically deliverable field settings

机译:肿瘤治疗场(TTFields)在临床上可交付使用的场设置下对小儿脑肿瘤细胞系具有抗增殖作用

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摘要

INTRODUCTIONApproximately 400 children in the UK are diagnosed with a CNS tumour each, which represents a quarter of childhood cancer cases in the UK. The overall 5-year survival rate of peadiatric brain tumour patients is roughly 75%, however survival still remains poor for some brain tumours, particularly high grade gliomas. Pre-clinical studies have shown efficacy of TTFields on high grade glioma cell lines, while TTFields have only been approved for adult Glioblastoma multiforme (GBM) patients in combination with the Stupp treatment protocol. The lack of overlapping toxicities associated with OptuneTM has made TTFields an attractive treatment strategy for poor prognosis brain tumours.
机译:简介在英国,大约有400名儿童被诊断出患有中枢神经系统肿瘤,占英国儿童期癌症病例的四分之一。小儿脑肿瘤患者的总体5年生存率约为75%,但是对于某些脑肿瘤,尤其是高级别神经胶质瘤,生存仍然很差。临床前研究表明,TTFields在高级别神经胶质瘤细胞系中具有疗效,而TTFields仅与成年胶质母细胞瘤(GBM)患者结合Stupp治疗方案被批准使用。缺乏与OptuneTM相关的重叠毒性,使得TTFields成为治疗预后不良的脑肿瘤的一种有吸引力的治疗策略。

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