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首页> 美国卫生研究院文献>Nutrients >An Increased Dietary Supply of Medium-Chain Fatty Acids during Early Weaning in Rodents Prevents Excessive Fat Accumulation in Adulthood
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An Increased Dietary Supply of Medium-Chain Fatty Acids during Early Weaning in Rodents Prevents Excessive Fat Accumulation in Adulthood

机译：啮齿动物早期断奶期间增加中链脂肪酸的饮食供应可防止成年期脂肪过多积聚

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Medium-chain fatty acids (MCFA) are a directly and readily absorbed source of energy. Exposure early-in-life to increased MCFA levels might affect development and impact (lipid) metabolism later in life. We tested whether an increased MCFA intake early-in-life positively affects adult body composition and metabolic status when challenged by a western-style diet (WSD). Male offspring of C57Bl/6j mice and Wistar rats were fed a control diet (CTRL; 10 w% fat, 14% MCFA) or a medium-chain triglycerides (MCT) diet with 20% MCFA until postnatal (PN) day 42, whereupon animals were fed a WSD (10 w% fat) until PN day 98. Body composition was monitored by Dual Energy X-ray Absorptiometry (DEXA). In rats, glucose homeostasis was assessed by glucose tolerance test (GTT) and insulin tolerance test (ITT); in mice, the HOmeostasis Model Assessment of Insulin Resistance (HOMA-IR) was calculated. At autopsy on PN day 98, plasma lipid profiles, glucose, insulin, and adipokines were measured; organs and fat pads were collected and the adipocyte size distribution was analysed. Milk analysis in mice showed that the maternal MCT diet was not translated into milk, and pups were thus only exposed to high MCT levels from early weaning onward: PN day 16 until 42. Mice exposed to MCT showed 28% less fat accumulation vs. CTRL during WSD. The average adipocyte cell size, fasting plasma triglycerides (TG), and leptin levels were reduced in MCT mice. In rats, no effects were found on the adult body composition, but the adipocyte cell size distribution shifted towards smaller adipocytes. Particularly mice showed positive effects on glucose homeostasis and insulin sensitivity. Increased MCFA intake early-in-life protected against the detrimental effects of an obesogenic diet in adulthood.
机译：中链脂肪酸（MCFA）是直接和容易吸收的能量来源。生命早期暴露于增加的MCFA水平可能会影响发育，并影响生命后期的（脂质）代谢。我们测试了在受到西式饮食（WSD）的挑战时，生命早期增加的MCFA摄入量是否对成年人的身体成分和代谢状态产生积极影响。给C57Bl / 6j小鼠和Wistar大鼠的雄性后代喂食对照饮食（CTRL; 10 w％脂肪，14％MCFA）或中链甘油三酸酯（MCT）饮食与20％MCFA，直到产后（PN）第42天，给动物喂食WSD（10 w％脂肪）直至PN第98天。通过双能X线吸收法（DEXA）监测身体成分。在大鼠中，通过葡萄糖耐量测试（GTT）和胰岛素耐量测试（ITT）评估葡萄糖稳态。在小鼠中，计算了胰岛素抵抗的高稳态模型评估（HOMA-IR）。在PN第98天进行尸检时，测量了血浆脂质，葡萄糖，胰岛素和脂肪因子。收集器官和脂肪垫，并分析脂肪细胞的大小分布。小鼠的乳汁分析表明，母体的MCT饮食未转化为乳汁，因此从断奶初期到PN第16天至42天，幼犬仅暴露于高水平的MCT。暴露于MCT的小鼠脂肪堆积比CTRL少28％在水务署期间。 MCT小鼠的平均脂肪细胞大小，空腹血浆甘油三酸酯（TG）和瘦素水平降低。在大鼠中，未发现对成年人体成分的影响，但是脂肪细胞的大小分布向较小的脂肪细胞转移。特别是小鼠对葡萄糖稳态和胰岛素敏感性显示出积极的作用。一生中增加MCFA的摄入量可以防止成年饮食对成年人的有害影响。

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