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首页> 美国卫生研究院文献>PPAR Research >Genetic Polymorphisms of Peroxisome Proliferator-Activated Receptors and the Risk of Cardiovascular Morbidity and Mortality in a Community-Based Cohort in Washington County Maryland
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Genetic Polymorphisms of Peroxisome Proliferator-Activated Receptors and the Risk of Cardiovascular Morbidity and Mortality in a Community-Based Cohort in Washington County Maryland

机译：过氧化物酶体增殖物激活受体的遗传多态性和在马里兰州华盛顿县的一个社区队列中心血管发病和死亡率的风险。

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The primary aim of this study was to examine prospectively the associations between 5 peroxisome proliferator-activated receptor (PPAR) single nucleotide polymorphisms (SNPs) and cardiovascular morbidity and mortality in a community-based cohort study in Washington County, Maryland. Data were analyzed from 9,364 Caucasian men and women participating in CLUE-II. Genotyping on 5 PPAR polymorphisms was conducted using peripheral DNA samples collected in 1989. The followup period was from 1989 to 2003. The results showed that there were no statistically significant associations between the PPAR SNPs and cardiovascular deaths or events. In contrast, statistically significant age-adjusted associations were observed for PPARG rs4684847 with both baseline body mass and blood pressure, and for PPARG rs709158, PPARG rs1175543, and PPARD rs2016520 with baseline cholesterol levels. Future studies should be conducted to confirm these findings and to explore the associations in populations with greater racial and ethnic diversity.
机译：这项研究的主要目的是在马里兰州华盛顿县的一项基于社区的队列研究中前瞻性检查5种过氧化物酶体增殖物激活受体（PPAR）单核苷酸多态性（SNPs）与心血管发病率和死亡率之间的关联。分析了参与CLUE-II的9,364名白人男女的数据。使用1989年收集的外周DNA样本对5个PPAR多态性进行基因分型。随访期为1989年至2003年。结果显示，PPAR SNP与心血管死亡或事件之间无统计学意义的关联。相比之下，在具有基线体重和血压的PPARG rs4684847和具有基线胆固醇水平的PPARG rs709158，PPARG rs1175543和PPARD rs2016520中，观察到了具有统计学意义的年龄校正关联。应该进行进一步的研究以证实这些发现并探索种族和族裔多样性更大的人群中的关联。

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