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首页> 美国卫生研究院文献>Preventive Nutrition and Food Science >Hepatic Fibrosis Inhibitory Effect of Peptides Isolated from Navicula incerta on TGF-β1 Induced Activation of LX-2 Human Hepatic Stellate Cells
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Hepatic Fibrosis Inhibitory Effect of Peptides Isolated from Navicula incerta on TGF-β1 Induced Activation of LX-2 Human Hepatic Stellate Cells

机译：cert皮分离肽对TGF-β1诱导的人肝星状细胞LX-2活化的抑制作用

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摘要

In this study, novel peptides (NIPP-1, NIPP-2) derived from Navicula incerta (microalgae) protein hydrolysate were explored for their inhibitory effects on collagen release in hepatic fibrosis with the investigation of its underlying mechanism of action. TGF-β1 activated fibrosis in LX-2 cells was examined in the presence or absence of purified peptides NIPP-1 and NIPP-2. Besides the mechanisms of liver cell injury, protective effects of NIPP-1 and NIPP-2 were studied to show the protective mechanism against TGF-β1 stimulated fibrogenesis. Our results showed that the core protein of NIPP-1 peptide prevented fibril formation of type I collagen, elevated the MMP level and inhibited TIMP production in a dose-dependent manner. The treatment of NIPP-1 and NIPP-2 on TGF-β1 induced LX-2 cells alleviated hepatic fibrosis. Moreover, α-SMA, TIMPs, collagen and PDGF in the NIPP-1 treated groups were significantly decreased. Therefore, it could be suggested that NIPP-1 has potential to be used in anti-fibrosis treatment.
机译：在这项研究中，通过研究其潜在的作用机理，研究了衍生自不育纳维克藻（微藻）蛋白水解物的新型肽（NIPP-1，NIPP-2）对肝纤维化中胶原释放的抑制作用。在存在或不存在纯化的肽NIPP-1和NIPP-2的情况下，检查LX-2细胞中TGF-β1激活的纤维化。除了研究肝细胞损伤的机制外，还研究了NIPP-1和NIPP-2的保护作用，以证明其对TGF-β1刺激的纤维化的保护作用。我们的结果表明，NIPP-1肽的核心蛋白以剂量依赖的方式阻止了原纤维形成I型胶原蛋白，提高了MMP水平并抑制了TIMP的产生。 NIPP-1和NIPP-2对TGF-β1诱导的LX-2细胞的作用减轻了肝纤维化。此外，NIPP-1治疗组的α-SMA，TIMPs，胶原蛋白和PDGF明显降低。因此，可以暗示NIPP-1具有用于抗纤维化治疗的潜力。

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