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首页> 美国卫生研究院文献>Proceedings of the National Academy of Sciences of the United States of America >Recruitment of a penicillin-binding protein gene from Neisseria flavescens during the emergence of penicillin resistance in Neisseria meningitidis.
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Recruitment of a penicillin-binding protein gene from Neisseria flavescens during the emergence of penicillin resistance in Neisseria meningitidis.

机译：在脑膜炎奈瑟氏球菌对青霉素的耐药性出现期间从短鞭状奈瑟氏菌中招募青霉素结合蛋白基因。

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摘要

Non-beta-lactamase-producing, penicillin-resistant strains of Neisseria meningitidis produce altered forms of penicillin-binding protein 2 that have decreased affinity for penicillin. The sequence of the penicillin-binding protein 2 gene (penA) from a penicillin-resistant strain of N. meningitidis was compared to the sequence of the same gene from penicillin-sensitive strains and from penicillin-sensitive and penicillin-resistant strains of Neisseria gonorrhoeae. The penA genes from penicillin-sensitive strains of N. gonorrhoeae and N. meningitidis were 98% identical. The gene from the penicillin-resistant strain of N. meningitidis consisted of regions that were almost identical to the corresponding regions in the penicillin-sensitive strains (less than 0.2% divergence) and two regions that were very different from them (approximately 22% divergence). The two blocks of altered sequence have arisen by the replacement of meningococcal sequences with the corresponding regions from the penA gene of Neisseria flavescens and result in an altered form of penicillin-binding protein 2 that contains 44 amino acid substitutions and 1 amino acid insertion compared to penicillin-binding protein 2 of penicillin-sensitive strains of N. meningitidis. A similar introduction of part of the penA gene of N. flavescens, or a very similar commensal Neisseria species, appears to have occurred independently during the development of altered penA genes in non-beta-lactamase-producing penicillin-resistant strains of N. gonorrhoeae.
机译：脑膜炎奈瑟氏球菌的非β-内酰胺酶生产性，抗青霉素菌株产生改变形式的青霉素结合蛋白2，对青霉素的亲和力降低。将来自脑膜炎奈瑟氏菌的抗青霉素菌株的青霉素结合蛋白2基因（penA）的序列与来自淋病奈瑟菌的青霉素敏感和青霉素耐药菌株的同一基因的序列进行比较。 。淋病奈瑟菌和脑膜炎奈瑟菌对青霉素敏感的菌株的penA基因具有98％的同一性。来自脑膜炎奈瑟氏菌的青霉素抗性菌株的基因由与青霉素敏感菌株的相应区域几乎相同的区域组成（差异小于0.2％）和与它们非常不同的两个区域（差异约为22％）组成）。改变序列的两个区块是通过用黄萎病奈瑟氏球菌penA基因的相应区域替换脑膜炎球菌序列而产生的，从而导致青霉素结合蛋白2的形式发生了变化，与2种相比，它含有44个氨基酸取代和1个氨基酸插入。脑膜炎奈瑟氏菌对青霉素敏感的菌株的青霉素结合蛋白2。在非生产β-内酰胺酶的耐青霉素性淋病奈瑟氏球菌菌株中，改变的penA基因的发育过程中，黄褐猪笼草penA基因的部分相似引入或非常相似的共生奈瑟菌属物种似乎已独立发生。 。

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